Warren S. Alexander
Active 1985–2025
- 108
- Papers
- 28,108
- Citations
- 86
- h-index
- 107
- i10-index
Citations
Citation sources
Countries
Institutions
Fields
- Medicine41.5%
- Biochemistry, Genetics and Molecular Biology36.3%
- Immunology and Microbiology14.8%
- Neuroscience4.9%
- Agricultural and Biological Sciences0.8%
- Nursing0.4%
- Other1.3%
Topics
- Cytokine Signaling Pathways and Interactions5.3%
- Immune Cell Function and Interaction4%
- Cell death mechanisms and regulation3.8%
- interferon and immune responses3.3%
- Inflammasome and immune disorders3.2%
- Immune Response and Inflammation2.2%
- Other78.2%
Coauthors
- Douglas J. Hilton50
- Donald Metcalf36
- Nicos A. Nicola34
- Jian‐Guo Zhang24
- Tracy A. Willson21
- Robyn Starr16
- Benjamin T. Kile13
- Jason Corbin13
- Ladina Di Rago12
- Ashley P. Ng11
- Craig D. Hyland11
- John Silke11
- Andreas Strasser10
- Andrew W. Roberts10
- Gordon K. Smyth10
- Carolyn A. de Graaf9
- James M. Murphy9
- Sandra E. Nicholson9
- Ben A. Croker8
- Elizabeth M. Viney8
- Emma C. Josefsson8
- Ian J. Majewski8
- Jeffrey J. Babon8
- Maria Kauppi8
All papers
- The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism
Authors: James M. Murphy, Peter E. Czabotar, Joanne M. Hildebrand, Isabelle S. Lucet, Jian‐Guo Zhang, Silvia Álvarez-Díaz, Rowena S. Lewis, Najoua Lalaoui, Donald Metcalf, Andrew I. Webb, Samuel N. Young, Leila N. Varghese, Gillian M. Tannahill, Esme C. Hatchell, Ian J. Majewski, Toru Okamoto, Renwick C. J. Dobson, Douglas J. Hilton, Jeffrey J. Babon, Nicos A. Nicola, Andreas Strasser, John Silke, Warren S. Alexander - Immunity 2013 cited by 1,214
- Robust hyperparameter estimation protects against hypervariable genes and improves power to detect differential expression
Authors: Belinda Phipson, Stanley Lee, Ian J. Majewski, Warren S. Alexander, Gordon K. Smyth - The Annals of Applied Statistics 2016 cited by 988
- RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
Authors: Kate E. Lawlor, Nufail Khan, Alison Mildenhall, Motti Gerlic, Ben A. Croker, Akshay A. D’Cruz, Cathrine Hall, Sukhdeep K. Spall, Holly Anderton, Seth L. Masters, Maryam Rashidi, Ian P. Wicks, Warren S. Alexander, Yasuhiro Mitsuuchi, Christopher A. Benetatos, Stephen M. Condon, W. Wei‐Lynn Wong, John Silke, David L. Vaux, James E. Vince - Nature Communications 2015 cited by 641
- Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
Authors: Joanne M. Hildebrand, Maria C. Tanzer, Isabelle S. Lucet, Samuel N. Young, Sukhdeep K. Spall, Pooja Sharma, Catia L. Pierotti, Jean‐Marc Garnier, Renwick C. J. Dobson, Andrew I. Webb, Anne Tripaydonis, Jeffrey J. Babon, Mark D. Mulcair, M.J. Scanlon, Warren S. Alexander, Andrew F. Wilks, Peter E. Czabotar, Guillaume Lessène, James M. Murphy, John Silke - National Academy of Sciences, Proceedings of the National Academy of Sciences 2014 cited by 596
- CIS is a potent checkpoint in NK cell–mediated tumor immunity
Authors: Rebecca B. Delconte, Tatiana B. Kolesnik, Laura F. Dagley, Jai Rautela, Wei Shi, Eva Maria Putz, Kimberley Stannard, Jian‐Guo Zhang, Charis E. Teh, Matt Firth, Takashi Ushiki, Christopher E. Andoniou, Mariapia A. Degli‐Esposti, Phillip P. Sharp, C. Sanvitale, Giuseppe Infusini, Nicholas P. D. Liau, Edmond M. Linossi, Christopher J. Burns, Sebastian Carotta, Daniel H.D. Gray, Cyril Seillet, Dana S. Hutchinson, Gabrielle T. Belz, Andrew I. Webb, Warren S. Alexander, Shawn S.‐C. Li, Alex N. Bullock, Jeffrey J. Babon, Mark J. Smyth, Sandra E. Nicholson, Nicholas D. Huntington - Nature Immunology 2016 cited by 387
- RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis
Authors: James A. Rickard, Joanne A. O’Donnell, Joseph M. Evans, Najoua Lalaoui, Ashleigh R. Poh, TeWhiti Rogers, James E. Vince, Kate E. Lawlor, Robert L. Ninnis, Holly Anderton, Cathrine Hall, Sukhdeep K. Spall, Toby J. Phesse, Helen E. Abud, Louise H. Cengia, Jason Corbin, Sandra Mifsud, Ladina Di Rago, Donald Metcalf, Matthias Ernst, Grant Dewson, Andrew W. Roberts, Warren S. Alexander, James M. Murphy, Paul G. Ekert, Seth L. Masters, David L. Vaux, Ben A. Croker, Motti Gerlic, John Silke - Cell 2014 cited by 598
- The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis
Authors: Silvia Álvarez-Díaz, Christopher P. Dillon, Najoua Lalaoui, Maria C. Tanzer, Diego A. Rodríguez, Ann Lin, Marion Lebois, Razqallah Hakem, Emma C. Josefsson, Lorraine A. O’Reilly, John Silke, Warren S. Alexander, Douglas R. Green, Andreas Strasser - Immunity 2016 cited by 230
- The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
Authors: Jerry M. Adams, A. W. Harris, Carl A. Pinkert, Lynn M. Corcoran, Warren S. Alexander, Suzanne Cory, Richard D. Palmiter, Ralph L. Brinster - Nature 1985 cited by 1,793
- SOCS3 negatively regulates IL-6 signaling in vivo
Authors: Ben A. Croker, Danielle L. Krebs, Jian‐Guo Zhang, Sam Wormald, Tracy A. Willson, Edouard G. Stanley, Lorraine Robb, Christopher J. Greenhalgh, Irmgard Förster, Björn E. Clausen, Nicos A. Nicola, Donald Metcalf, Douglas J. Hilton, Andrew W. Roberts, Warren S. Alexander - Nature Immunology 2003 cited by 844
- A family of cytokine-inducible inhibitors of signalling
Authors: Robyn Starr, Tracy A. Willson, Elizabeth M. Viney, Leecia J. Murray, John R Rayner, Brendan J. Jenkins, Thomas J. Gonda, Warren S. Alexander, D Metcalf, Nicos A. Nicola, Douglas J. Hilton - Nature 1997 cited by 2,088
- The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal
Authors: Yuqing Yang, Andrew J. Kueh, Zoe L. Grant, Waruni Abeysekera, Alexandra L. Garnham, Stephen Wilcox, Craig D. Hyland, Ladina Di Rago, Don Metcalf, Warren S. Alexander, Leigh Coultas, Gordon K. Smyth, Anne K. Voss, Tim Thomas - Blood 2021 cited by 68
- Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells
Authors: Hong Qian, Natalija Buza-Vidas, Craig D. Hyland, Christina T. Jensen, Jennifer Antonchuk, Robert Månsson, Lina Thorén, Marja Ekblom, Warren S. Alexander, Sten Eirik W. Jacobsen - Cell stem cell 2007 cited by 544
- Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non‐apoptotic caspase‐8 is required for inflammasome priming
Authors: Ramanjaneyulu Allam, Kate E. Lawlor, Eric Yu, Alison Mildenhall, Donia M. Moujalled, Rowena S. Lewis, Francine Ke, Kylie D. Mason, M. J. D. White, Katryn J. Stacey, Andreas Strasser, Lorraine A. O’Reilly, Warren S. Alexander, Benjamin T. Kile, David L. Vaux, James E. Vince - EMBO Reports 2014 cited by 241
- Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
Authors: Stefan Glaser, Erinna F. Lee, Evelyn Trounson, Philippe Bouillet, Andrew H. Wei, W. Douglas Fairlie, David J. Izon, Johannes Zuber, Amy Rappaport, Marco J. Herold, Warren S. Alexander, Scott W. Lowe, Lorraine Robb, Andreas Strasser - Genes & Development 2012 cited by 418
- NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells
Authors: Seth L. Masters, Motti Gerlic, Donald Metcalf, Simon Preston, Marc Pellegrini, Joanne A. O’Donnell, Kate McArthur, Tracey M. Baldwin, Stéphane Chevrier, Cameron J. Nowell, Louise H. Cengia, Katya J. Henley, Janelle E. Collinge, Daniel L. Kastner, Lionel Feigenbaum, Douglas J. Hilton, Warren S. Alexander, Benjamin T. Kile, Ben A. Croker - Immunity 2012 cited by 320
- Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans
Authors: Jarny Choi, Tracey M. Baldwin, Mae Wong, Jessica E. Bolden, Kirsten A. Fairfax, Erin C. Lucas, Rebecca Cole, Christine Biben, Clare Morgan, Kerry A. Ramsay, Ashley P. Ng, Maria Kauppi, Lynn M. Corcoran, Wei Shi, Nick Wilson, Michael J. Wilson, Warren S. Alexander, Douglas J. Hilton, Carolyn A. de Graaf - Nucleic Acids Research, Nucleic Acids Res. 2018 cited by 175
- Twenty proteins containing a C-terminal SOCS box form five structural classes
Authors: Douglas J. Hilton, Rachael T. Richardson, Warren S. Alexander, Elizabeth M. Viney, Tracy A. Willson, Naomi S. Sprigg, Robyn Starr, Sandra E. Nicholson, Donald Metcalf, Nicos A. Nicola - National Academy of Sciences, Proceedings of the National Academy of Sciences 1998 cited by 747
- Suppressors of cytokine signalling (SOCS) in the immune system
Authors: Warren S. Alexander - Nature reviews. Immunology 2002 cited by 642
- NK cell–derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS
Authors: Cynthia Louis, Fernando Souza-Fonseca-Guimarães, Yuyan Yang, Damian B. D’Silva, Tobias Kratina, Laura F. Dagley, Soroor Hediyeh-zadeh, Jai Rautela, Seth L. Masters, Melissa J. Davis, Jeffrey J. Babon, Bogoljub Ćirić, Éric Vivier, Warren S. Alexander, Nicholas D. Huntington, Ian P. Wicks - The Journal of Experimental Medicine 2020 cited by 96
- TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice
Authors: James Rickard, Holly Anderton, Nima Etemadi, Ueli Nachbur, Maurice Darding, Nieves Peltzer, Najoua Lalaoui, Kate E. Lawlor, Hannah Vanyai, Cathrine Hall, Aleks Bankovacki, Lahiru Gangoda, W. Wei‐Lynn Wong, Jason Corbin, Chunzi Huang, Edward S. Mocarski, James M. Murphy, Warren S. Alexander, Anne K. Voss, David L. Vaux, William J. Kaiser, Henning Walczak, John Silke - eLife 2014 cited by 264
- A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
Authors: Joanne M. Hildebrand, Maria Kauppi, Ian J. Majewski, Zikou Liu, Allison Cox, Sanae Miyake, Emma J. Petrie, Michael Silk, Zhixiu Li, Maria C. Tanzer, Gabriela Brumatti, Samuel N. Young, Cathrine Hall, Sarah E. Garnish, Jason Corbin, Michael D. Stutz, Ladina Di Rago, Pradnya Gangatirkar, Emma C. Josefsson, Kristin A. Rigbye, Holly Anderton, James Rickard, Anne Tripaydonis, Julie M. Sheridan, Thomas Scerri, Victoria E. Jackson, Peter E. Czabotar, Jian‐Guo Zhang, Leila N. Varghese, Cody C. Allison, Marc Pellegrini, Gillian M. Tannahill, Esme C. Hatchell, Tracy A. Willson, Dina Stockwell, Carolyn A. de Graaf, Janelle E. Collinge, Adrienne A. Hilton, Natasha Silke, Sukhdeep K. Spall, Diep Chau, Vicki Athanasopoulos, Donald Metcalf, Ronald M. Laxer, Alexander G. Bassuk, Benjamin W. Darbro, Maria A. Fiatarone Singh, Nicole Vlahovich, David Hughes, Maria Kozlovskaia, David B. Ascher, Klaus Warnatz, Nils Venhoff, Jens Thiel, Christine Biben, Stefan Blum, John D. Reveille, Michael S. Hildebrand, Carola G. Vinuesa, Pamela McCombe, Matthew A. Brown, Benjamin T. Kile, Catriona McLean, Melanie Bahlo, Seth L. Masters, Hiroyasu Nakano, Polly J. Ferguson, James M. Murphy, Warren S. Alexander, John Silke - Nature Communications 2020 cited by 95
- Out-of-Sequence Signal 3 Paralyzes Primary CD4+ T-Cell-Dependent Immunity
Authors: Gail D. Sckisel, Myriam N. Bouchlaka, Arta M. Monjazeb, Marka R. Crittenden, Brendan D. Curti, Danice Wilkins, Kory A. Alderson, Can M. Sungur, Erik Ames, Annie Mirsoian, Abhinav Reddy, Warren S. Alexander, Athena M. Soulika, Bruce R. Blazar, Dan L. Longo, Robert H. Wiltrout, William J. Murphy - Immunity 2015 cited by 106
- SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine
Authors: Warren S. Alexander, Robyn Starr, Jennifer E Fenner, Clare L. Scott, Emanuela Handman, Naomi S. Sprigg, Jason Corbin, Ann L. Cornish, Rima Darwiche, Catherine M. Owczarek, Thomas W. H. Kay, Nicos A. Nicola, Paul J. Hertzog, Donald Metcalf, Douglas J. Hilton - Cell 1999 cited by 764
- cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner
Authors: W. Wei‐Lynn Wong, James E. Vince, Najoua Lalaoui, Kate E. Lawlor, Diep Chau, Aleksandra Bankovacki, Holly Anderton, Donald Metcalf, Lorraine A. O’Reilly, Philipp J. Jost, James M. Murphy, Warren S. Alexander, Andreas Strasser, David L. Vaux, John Silke - Blood 2014 cited by 162
