Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy

Authors: Noor Momin, Naveen K. Mehta, Nitasha R. Bennett, Leyuan Ma, Joseph R. Palmeri, Magnolia M. Chinn, Emi A. Lutz, Byong H. Kang, Darrell J. Irvine, Stefani Spranger, K. Dane Wittrup - Science Translational Medicine 2019 cited by 208

T cell response primed by local therapy. Cytokine collagen-anchoring constitutes a facile, tumor-agnostic strategy to safely potentiate otherwise marginally effective systemic immunotherapies.