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Darrell J. Irvine

Active 2000–2026

203
Papers
34,141
Citations
101
h-index
189
i10-index

Citations

Citations per year for Darrell J. Irvine1896: 2 citations1990: 2 citations1992: 1 citations1998: 1 citations2000: 1 citations2002: 11 citations2003: 27 citations2004: 49 citations2005: 77 citations2006: 76 citations2007: 84 citations2008: 83 citations2009: 115 citations2010: 101 citations2011: 133 citations2012: 258 citations2013: 263 citations2014: 300 citations2015: 370 citations2016: 409 citations2017: 522 citations2018: 538 citations2019: 1,507 citations2020: 1,988 citations2021: 2,150 citations2022: 1,843 citations2023: 1,697 citations2024: 2,386 citations2025: 1,295 citations2026: 45 citations1897–1989: no citations, so these years are not shown1991: no citations, so this year is not shown1993–1997: no citations, so these years are not shown1999: no citations, so this year is not shown2001: no citations, so this year is not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 5,032 citing papers, 30% of this breakdownChina: 3,367 citing papers, 20.1% of this breakdownUnited Kingdom: 786 citing papers, 4.7% of this breakdownGermany: 633 citing papers, 3.8% of this breakdownSouth Korea: 474 citing papers, 2.8% of this breakdownCanada: 426 citing papers, 2.5% of this breakdownFrance: 422 citing papers, 2.5% of this breakdownAustralia: 415 citing papers, 2.5% of this breakdownIndia: 398 citing papers, 2.4% of this breakdownItaly: 397 citing papers, 2.4% of this breakdownNetherlands: 335 citing papers, 2% of this breakdownSwitzerland: 309 citing papers, 1.8% of this breakdown
0%30%Other 22.5%

Institutions

Fields

  • Immunology and Microbiology27.2%
  • Biochemistry, Genetics and Molecular Biology26.4%
  • Medicine22.8%
  • Engineering8.8%
  • Materials Science6.9%
  • Pharmacology, Toxicology and Pharmaceutics4.8%
  • Other3.1%

Topics

  • Immunotherapy and Immune Responses8.8%
  • RNA Interference and Gene Delivery6%
  • Nanoplatforms for cancer theranostics4.5%
  • Immune Cell Function and Interaction4%
  • CAR-T cell therapy research3.5%
  • Nanoparticle-Based Drug Delivery3.2%
  • Other70%

Coauthors

All papers

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  1. Enhancing cancer immunotherapy with nanomedicine

    Authors: Darrell J. Irvine, Eric L. Dane - Nature reviews. Immunology 2020 cited by 851

  2. STING agonist delivery by tumour-penetrating PEG-lipid nanodiscs primes robust anticancer immunity

    Authors: Eric L. Dane, Alexis Belessiotis‐Richards, Coralie M. Backlund, Jianing Wang, Kousuke Hidaka, Lauren E. Milling, Sachin Bhagchandani, Mariane B. Melo, Shengwei Wu, Na Li, Nathan D. Donahue, Kaiyuan Ni, Leyuan Ma, Masanori Okaniwa, Molly M. Stevens, Alfredo Alexander‐Katz, Darrell J. Irvine - Nature Materials 2022 cited by 320

  3. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

    Authors: Christian M. Metallo, Paulo A. Gameiro, Eric L. Bell, Katherine Mattaini, Juanjuan Yang, Karsten Hiller, Christopher M. Jewell, Zachary Johnson, Darrell J. Irvine, Leonard Guarente, Joanne K. Kelleher, Matthew G. Vander Heiden, Othon Iliopoulos, Gregory Stephanopoulos - Nature 2011 cited by 1,803

  4. Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery

    Authors: Li Tang, Yiran Zheng, Mariane B. Melo, Llian Mabardi, Ana P. Castaño, Yuqing Xie, Na Li, Sagar B. Kudchodkar, Hing C. Wong, Emily K. Jeng, Marcela V. Maus, Darrell J. Irvine - Nature Biotechnology 2018 cited by 646

  5. Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity

    Authors: Leyuan Ma, Alexander Hostetler, Duncan M. Morgan, Laura Maiorino, Ina Sulkaj, Charles A. Whittaker, Alexandra Neeser, Ivan S. Pires, Parisa Yousefpour, Justin M. Gregory, Kashif Qureshi, Jonathan Dye, Wuhbet Abraham, Heikyung Suh, Na Li, J. Christopher Love, Darrell J. Irvine - Cell 2023 cited by 212

  6. Structure-based programming of lymph-node targeting in molecular vaccines

    Authors: Haipeng Liu, Kelly D. Moynihan, Yiran Zheng, Gregory L. Szeto, Adrienne V. Li, Bonnie Huang, Debra Van Egeren, Clara Park, Darrell J. Irvine - Nature 2014 cited by 951

  7. Human STING is a proton channel

    Authors: Bingxu Liu, Rebecca J. Carlson, Ivan S. Pires, Matteo Gentili, Ellie Feng, Quentin Hellier, Marc A. Schwartz, Paul C. Blainey, Darrell J. Irvine, Nir Hacohen - Science 2023 cited by 197

  8. Enhanced CAR–T cell activity against solid tumors by vaccine boosting through the chimeric receptor

    Authors: Leyuan Ma, Tanmay Dichwalkar, Jason Y.H. Chang, Benjamin Cossette, Daniel Garafola, Angela Q. Zhang, Michael Fichter, Chensu Wang, Simon Liang, Murillo Silva, Sudha Kumari, Naveen K. Mehta, Wuhbet Abraham, Nikki Thai, Na Li, K. Dane Wittrup, Darrell J. Irvine - Science 2019 cited by 431

  9. Role of nanoscale antigen organization on B-cell activation probed using DNA origami

    Authors: Rémi Veneziano, Tyson J. Moyer, Matthew B. Stone, Eike‐Christian Wamhoff, Benjamin J. Read, Sayak Mukherjee, Tyson R. Shepherd, Jayajit Das, William R. Schief, Darrell J. Irvine, Mark Bathe - Nature Nanotechnology 2020 cited by 442

  10. Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity

    Authors: Yingzhong Li, Zhijun Su, Weiyu Zhao, Xinfu Zhang, Noor Momin, Chengxiang Zhang, K. Dane Wittrup, Yizhou Dong, Darrell J. Irvine, Ron Weiss - Nature Cancer 2020 cited by 235

  11. Long-primed germinal centres with enduring affinity maturation and clonal migration

    Authors: Jeong Hyun Lee, Henry J. Sutton, Christopher A. Cottrell, Ivy Phung, Gabriel Ozorowski, Leigh M. Sewall, Rebecca Nedellec, Catherine Nakao, Murillo Silva, Sara T. Richey, Jonathan L. Torres, Wen-Hsin Lee, Erik Georgeson, Michael Kubitz, Sam Hodges, Tina-Marie Mullen, Yumiko Adachi, Kimberly M. Cirelli, Amitinder Kaur, Carolina Allers, Marissa Fahlberg, Brooke Grasperge, Jason Dufour, Faith Schiro, Pyone P. Aye, Oleksandr Kalyuzhniy, Alessia Liguori, Diane G. Carnathan, Guido Silvestri, Xiaoying Shen, David C. Montefiori, Ronald S. Veazey, Andrew B. Ward, Lars Hangartner, Dennis R. Burton, Darrell J. Irvine, William R. Schief, Shane Crotty - Nature 2022 cited by 192

  12. Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

    Authors: Kimberly M. Cirelli, Diane G. Carnathan, Bartek Nogal, Jacob T. Martin, Oscar L. Rodriguez, Amit A. Upadhyay, Chiamaka A. Enemuo, Etse H. Gebru, Yury Choe, Federico Viviano, Catherine Nakao, Matthias Pauthner, Samantha Reiss, Christopher A. Cottrell, Melissa Smith, Raiza Bastidas, William Gibson, Amber Wolabaugh, Mariane B. Melo, Benjamin Cossette, Venkatesh Kumar, Nirav Patel, Talar Tokatlian, Sergey Menis, Daniel W. Kulp, Dennis R. Burton, Ben Murrell, William R. Schief, Steven E. Bosinger, Andrew B. Ward, Corey T. Watson, Guido Silvestri, Darrell J. Irvine, Shane Crotty - Cell 2019 cited by 470

  13. The future of engineered immune cell therapies

    Authors: Darrell J. Irvine, Marcela V. Maus, David Mooney, Wilson W. Wong - Science 2022 cited by 190

  14. Synthetic Nanoparticles for Vaccines and Immunotherapy

    Authors: Darrell J. Irvine, Melissa C. Hanson, Kavya Rakhra, Talar Tokatlian - Chemical Reviews 2015 cited by 743

  15. Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses

    Authors: Kelly D. Moynihan, Cary F. Opel, Gregory L. Szeto, Alice Tzeng, Eric Zhu, J Engreitz, Christina Williamson, Kavya Rakhra, Michael H. Zhang, Adrienne M. Rothschilds, Sudha Kumari, Ryan L. Kelly, Byron H. Kwan, Wuhbet Abraham, Kevin Hu, Naveen K. Mehta, Monique J. Kauke, Heikyung Suh, Jennifer R. Cochran, Douglas A. Lauffenburger, K. Dane Wittrup, Darrell J. Irvine - Nature Medicine 2016 cited by 538

  16. Bio-inspired, bioengineered and biomimetic drug delivery carriers

    Authors: Jin‐Wook Yoo, Darrell J. Irvine, Dennis E. Discher, Samir Mitragotri - Nature Reviews Drug Discovery 2011 cited by 1,221

  17. Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer

    Authors: Peter M.K. Westcott, Nathan Sacks, Jason M. Schenkel, Zackery A. Ely, Olivia Smith, Haley Hauck, Alex M. Jaeger, Daniel Zhang, Coralie M. Backlund, Mary C. Beytagh, J. J. Patten, Ryan Elbashir, George Eng, Darrell J. Irvine, Omer H. Yilmaz, Tyler Jacks - Nature Cancer 2021 cited by 166

  18. Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo

    Authors: Yu Kato, Robert Abbott, Brian L. Freeman, Sonya Haupt, Bettina Gröschel, Murillo Silva, Sergey Menis, Darrell J. Irvine, William R. Schief, Shane Crotty - Immunity 2020 cited by 281

  19. Controlling timing and location in vaccines

    Authors: Darrell J. Irvine, Aereas Aung, Murillo Silva - Advanced Drug Delivery Reviews 2020 cited by 262

  20. Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants

    Authors: Sachin Bhagchandani, Jeremiah A. Johnson, Darrell J. Irvine - Advanced Drug Delivery Reviews 2021 cited by 185

  21. Therapeutic cell engineering with surface-conjugated synthetic nanoparticles

    Authors: Matthias T. Stephan, James J. Moon, Soong Ho Um, Anna Bershteyn, Darrell J. Irvine - Nature Medicine 2010 cited by 738

  22. T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity

    Authors: Daniela Schmid, Chun Gwon Park, Christina Hartl, Nikita Subedi, Adam N.R. Cartwright, Regina Bou-Puerto, Yiran Zheng, James Maiarana, Gordon J. Freeman, Kai W. Wucherpfennig, Darrell J. Irvine, Michael S. Goldberg - Nature Communications 2017 cited by 441

  23. Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination

    Authors: Hok Hei Tam, Mariane B. Melo, Myungsun Kang, Jeisa M. Pelet, Vera M. Ruda, Maria Hottelet Foley, Joyce Hu, Sudha Kumari, Jordan Crampton, Alexis D. Baldeon, Rogier W. Sanders, John P. Moore, Shane Crotty, Róbert Langer, Daniel G. Anderson, Arup K. Chakraborty, Darrell J. Irvine - National Academy of Sciences, Proceedings of the National Academy of Sciences 2016 cited by 434

  24. A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity

    Authors: Murillo Silva, Yu Kato, Mariane B. Melo, Ivy Phung, Brian L. Freeman, Zhong‐Ming Li, Kangsan Roh, Jan Willem van Wijnbergen, Hannah C. Watkins, Chiamaka A. Enemuo, Brittany L. Hartwell, Jason Y.H. Chang, Shuhao Xiao, Kristen A. Rodrigues, Kimberly M. Cirelli, Na Li, Sonya Haupt, Aereas Aung, Benjamin Cossette, Wuhbet Abraham, Swati Kataria, Raiza Bastidas, Jinal N. Bhiman, Caitlyn Linde, Nathaniel I. Bloom, Bettina Gröschel, Erik Georgeson, Nicole Phelps, Ayush Thomas, Julia Bals, Diane G. Carnathan, Daniel Lingwood, Dennis R. Burton, Galit Alter, Timothy P. Padera, Angela M. Belcher, William R. Schief, Guido Silvestri, Ruth M. Ruprecht, Shane Crotty, Darrell J. Irvine - Science Immunology 2021 cited by 174