Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

Authors: Kristen E. Pauken, Morgan A. Sammons, Pamela M. Odorizzi, Sasikanth Manne, Jernej Godec, Omar Khan, Adam Drake, Zeyu Chen, Debattama R. Sen, Makoto Kurachi, R. Anthony Barnitz, Caroline Bartman, Bertram Bengsch, Alexander C. Huang, Jason M. Schenkel, Golnaz Vahedi, W. Nicholas Haining, Shelley L. Berger, E. John Wherry - Science 2016 cited by 1,348

epigenetic landscape. These data indicate that epigenetic fate inflexibility may limit current immunotherapies.