Brendan D. Manning
1996–2025 年に発表
- 80
- 論文数
- 41,423
- 被引用数
- 70
- h 指数
- 76
- i10 指数
被引用数
引用元
国・地域
機関
分野
- Biochemistry, Genetics and Molecular Biology53.4%
- Medicine34%
- Immunology and Microbiology5.2%
- Neuroscience3.2%
- Agricultural and Biological Sciences1.3%
- Nursing0.5%
- その他2.4%
トピック
- PI3K/AKT/mTOR signaling in cancer7.1%
- Cancer, Hypoxia, and Metabolism4%
- Autophagy in Disease and Therapy3.2%
- Metabolism, Diabetes, and Cancer3%
- Epigenetics and DNA Methylation1.7%
- RNA modifications and cancer1.7%
- その他79.3%
共著者
- John M. Asara19
- Issam Ben‐Sahra15
- Lewis C. Cantley11
- Gerta Hoxhaj10
- David J. Kwiatkowski9
- Suchithra Menon9
- Christian C. Dibble8
- Jessica L. Yecies7
- Stéphane J. H. Ricoult7
- Alexander J. Valvezan6
- Mustafa Şahin6
- Vanessa Byles6
- Jessica J. Howell5
- Jingxiang Huang5
- Aaron M. Hosios4
- Alex Lipovsky4
- Huihui Zhang4
- John Blenis4
- Krystle C. Kalafut4
- Margaret E. Torrence4
- Min Yuan4
- Peng Gao4
- Sandra Schrötter4
- Yinan Zhang4
全論文
- AKT/PKB Signaling: Navigating the Network
著者: Brendan D. Manning, Alex Toker - Cell 2017 被引用: 3,790
- The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism
著者: Gerta Hoxhaj, Brendan D. Manning - Nature reviews. Cancer 2019 被引用: 2,147
- AKT/PKB Signaling: Navigating Downstream
著者: Brendan D. Manning, Lewis C. Cantley - Cell 2007 被引用: 6,119
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
著者: Katrin Düvel, Jessica L. Yecies, Suchithra Menon, Pichai Raman, Alex Lipovsky, Amanda L. Souza, Ellen Triantafellow, Qicheng Ma, Regina Gorski, Stephen Cleaver, Matthew G. Vander Heiden, Jeffrey P. MacKeigan, Peter M. Finan, Clary B. Clish, Leon O. Murphy, Brendan D. Manning - Molecular Cell 2010 被引用: 1,979
- Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
著者: William E. Dowdle, Beat Nyfeler, Jane Nagel, R.A. Elling, Shanming Liu, Ellen Triantafellow, Suchithra Menon, Zuncai Wang, Ayako Honda, Gwynn Pardee, John Cantwell, Catherine A. Luu, Iván Cornella‐Taracido, Edmund Harrington, Peter Fekkes, Hong Lei, Qing Fang, Mary Ellen Digan, Debra Burdick, Andrew F. Powers, Stephen B. Helliwell, Simon d‘Aquin, Julie Bastien, Henry Wang, Dmitri Wiederschain, Jenny Kuerth, Philip J. Bergman, David J. Schwalb, Jason R. Thomas, Savuth Ugwonali, Fred Harbinski, John A. Tallarico, Christopher J. Wilson, Vic E. Myer, Jeffery A. Porter, Dirksen E. Bussiere, Peter M. Finan, Mark Labow, Xiaohong Mao, Lawrence G. Hamann, Brendan D. Manning, Reginald Valdez, Thomas Nicholson, Markus Schirle, Mark Knapp, Erin P. Keaney, Leon O. Murphy - Nature Cell Biology 2014 被引用: 740
- mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
著者: Issam Ben‐Sahra, Gerta Hoxhaj, Stéphane J. H. Ricoult, John M. Asara, Brendan D. Manning - Science 2016 被引用: 818
- The TSC-mTOR pathway regulates macrophage polarization
著者: Vanessa Byles, Anthony J. Covarrubias, Issam Ben‐Sahra, Dudley W. Lamming, David M. Sabatini, Brendan D. Manning, Tiffany Horng - Nature Communications 2013 被引用: 627
- Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex
著者: Jessica J. Howell, Kristina Hellberg, Marc Turner, George Talbott, Matthew J. Kolar, Debbie S. Ross, Gerta Hoxhaj, Alan Saghatelian, Reuben J. Shaw, Brendan D. Manning - Cell Metabolism 2017 被引用: 405
- Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways
著者: Jessica L. Yecies, Huihui Zhang, Suchithra Menon, Sihao Liu, Derek Yecies, Alex Lipovsky, Cem Z. Görgün, David J. Kwiatkowski, Gökhan S. Hotamışlıgil, Chih‐Hao Lee, Brendan D. Manning - Cell Metabolism 2011 被引用: 634
- Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation
著者: Anthony J. Covarrubias, Halil‐Ibrahim Aksoylar, Jiujiu Yu, Nathaniel W. Snyder, Andrew J. Worth, Shankar S. Iyer, Jiawei Wang, Issam Ben‐Sahra, Vanessa Byles, Tiffany Polynne-Stapornkul, Erika C Espinosa, Dudley W. Lamming, Brendan D. Manning, Yijing Zhang, Ian A. Blair, Tiffany Horng - eLife 2016 被引用: 441
- Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1
著者: Issam Ben‐Sahra, Jessica J. Howell, John M. Asara, Brendan D. Manning - Science 2013 被引用: 739
- Molecular logic of mTORC1 signalling as a metabolic rheostat
著者: Alexander J. Valvezan, Brendan D. Manning - Nature Metabolism 2019 被引用: 330
- mTORC1 signaling and the metabolic control of cell growth
著者: Issam Ben‐Sahra, Brendan D. Manning - Current Opinion in Cell Biology 2017 被引用: 651
- Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome
著者: Suchithra Menon, Christian C. Dibble, George Talbott, Gerta Hoxhaj, Alexander J. Valvezan, Hidenori Takahashi, Lewis C. Cantley, Brendan D. Manning - Cell 2014 被引用: 784
- The TSC1–TSC2 complex: a molecular switchboard controlling cell growth
著者: Jingxiang Huang, Brendan D. Manning - Biochemical Journal 2008 被引用: 1,240
- Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production
著者: Alban Longchamp, Teodelinda Mirabella, Alessandro Arduini, Michael R. MacArthur, Abhirup Das, J. Humberto Treviño-Villarreal, Christopher Hine, Issam Ben‐Sahra, Nelson H. Knudsen, Lear E. Brace, Justin S. Reynolds, Pedro Mejia, Ming Tao, Gaurav Sharma, Rui Wang, Jean-Marc Corpataux, Jacques‐Antoine Haefliger, Kyo Han Ahn, Chih‐Hao Lee, Brendan D. Manning, David Sinclair, Christopher S. Chen, C. Keith Ozaki, James R. Mitchell - Cell 2018 被引用: 333
- Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
著者: James Brugarolas, Kui Lei, Rebecca L. Hurley, Brendan D. Manning, Jan H. Reiling, Ernst Hafen, Lee A. Witters, Leif W. Ellisen, William G. Kaelin - Genes & Development 2004 被引用: 1,376
- Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP
著者: Stéphane J. H. Ricoult, Jessica L. Yecies, Issam Ben‐Sahra, Brendan D. Manning - Oncogene 2015 被引用: 280
- Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb
著者: Andrew R. Tee, Brendan D. Manning, Philippe P. Roux, Lewis C. Cantley, John Blenis - Current Biology 2003 被引用: 1,210
- Signal integration by mTORC1 coordinates nutrient input with biosynthetic output
著者: Christian C. Dibble, Brendan D. Manning - Nature Cell Biology 2013 被引用: 721
- TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1
著者: Christian C. Dibble, Winfried Elis, Suchithra Menon, Wei Qin, Justin Klekota, John M. Asara, Peter M. Finan, David J. Kwiatkowski, Leon O. Murphy, Brendan D. Manning - Molecular Cell 2012 被引用: 613
- The LKB1 tumor suppressor negatively regulates mTOR signaling
著者: Reuben J. Shaw, Nabeel Bardeesy, Brendan D. Manning, Lyle V. Lopez, Monica Kosmatka, Ronald A. DePinho, Lewis C. Cantley - Cancer Cell 2004 被引用: 1,065
- Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway
著者: Brendan D. Manning, Andrew R. Tee, M. Nicole Logsdon, John Blenis, Lewis C. Cantley - Molecular Cell 2002 被引用: 1,553
- Direct stimulation of NADP + synthesis through Akt-mediated phosphorylation of NAD kinase
著者: Gerta Hoxhaj, Issam Ben‐Sahra, Sophie E. Lockwood, Rebecca C. Timson, Vanessa Byles, Graham T. Henning, Peng Gao, Laura M. Selfors, John M. Asara, Brendan D. Manning - Science 2019 被引用: 143
