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William G. Kaelin

1990–2025 年に発表

185
論文数
65,039
被引用数
135
h 指数
183
i10 指数

被引用数

William G. Kaelin の年別被引用数1956 年: 被引用 1 件1989 年: 被引用 1 件1990 年: 被引用 1 件1991 年: 被引用 28 件1992 年: 被引用 93 件1993 年: 被引用 184 件1994 年: 被引用 207 件1995 年: 被引用 221 件1996 年: 被引用 270 件1997 年: 被引用 283 件1998 年: 被引用 317 件1999 年: 被引用 501 件2000 年: 被引用 546 件2001 年: 被引用 698 件2002 年: 被引用 901 件2003 年: 被引用 881 件2004 年: 被引用 894 件2005 年: 被引用 807 件2006 年: 被引用 780 件2007 年: 被引用 679 件2008 年: 被引用 654 件2009 年: 被引用 709 件2010 年: 被引用 717 件2011 年: 被引用 676 件2012 年: 被引用 664 件2013 年: 被引用 688 件2014 年: 被引用 723 件2015 年: 被引用 579 件2016 年: 被引用 611 件2017 年: 被引用 650 件2018 年: 被引用 531 件2019 年: 被引用 1,623 件2020 年: 被引用 1,992 件2021 年: 被引用 1,857 件2022 年: 被引用 1,411 件2023 年: 被引用 1,043 件2024 年: 被引用 1,637 件2025 年: 被引用 738 件2026 年: 被引用 13 件1957〜1988 年は被引用が無いため表示していません

引用元

国・地域

この著者を引用した国・地域の世界地図アメリカ合衆国: 引用元論文 8,653 件、この内訳の 35.8%中国: 引用元論文 2,716 件、この内訳の 11.2%イギリス: 引用元論文 1,811 件、この内訳の 7.5%ドイツ: 引用元論文 1,324 件、この内訳の 5.5%日本: 引用元論文 910 件、この内訳の 3.8%フランス: 引用元論文 858 件、この内訳の 3.5%カナダ: 引用元論文 824 件、この内訳の 3.4%イタリア: 引用元論文 771 件、この内訳の 3.2%スペイン: 引用元論文 498 件、この内訳の 2.1%オーストラリア: 引用元論文 457 件、この内訳の 1.9%スイス: 引用元論文 436 件、この内訳の 1.8%オランダ: 引用元論文 434 件、この内訳の 1.8%
0%35.8%その他 18.5%

機関

分野

  • Biochemistry, Genetics and Molecular Biology57.3%
  • Medicine35.3%
  • Immunology and Microbiology2.7%
  • Neuroscience1.2%
  • Agricultural and Biological Sciences0.9%
  • Chemistry0.5%
  • その他2.1%

トピック

  • Cancer, Hypoxia, and Metabolism9.4%
  • Cancer-related Molecular Pathways5.1%
  • Epigenetics and DNA Methylation4.2%
  • Ubiquitin and proteasome pathways4.2%
  • RNA modifications and cancer2.7%
  • Protein Degradation and Inhibitors2.2%
  • その他72.2%

共著者

全論文

検索で開く
  1. Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

    著者: William G. Kaelin, Peter J. Ratcliffe - Molecular Cell 2008 被引用: 3,236

  2. The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

    著者: Gang Lu, Richard E. Middleton, Huahang Sun, MarkVic Naniong, Christopher J. Ott, Constantine S. Mitsiades, Kwok‐Kin Wong, James E. Bradner, William G. Kaelin - Science 2013 被引用: 1,582

  3. HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing

    著者: Mircea Ivan, Keiichi Kondo, Haifeng Yang, William Kim, Jennifer Valiando, Michael Ohh, Adrian Salic, John M. Asara, William S. Lane, William G. Kaelin - Science 2001 被引用: 4,724

  4. Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma

    著者: Diana Miao, Claire A. Margolis, Wenhua Gao, Martin H. Voss, Wei Li, Dylan J. Martini, Craig Norton, Dominick Bossé, Stephanie A. Wankowicz, Dana Cullen, Christine E. Horak, Megan Wind‐Rotolo, Adam Tracy, Marios Giannakis, F. Stephen Hodi, Charles G. Drake, Mark W. Ball, Mohamad E. Allaf, Alexandra Snyder, Matthew D. Hellmann, Thai H. Ho, Robert J. Motzer, Sabina Signoretti, William G. Kaelin, Toni K. Choueiri, Eliezer M. Van Allen - Science 2018 被引用: 1,313

  5. Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions

    著者: Julie J. Miller, L. Nicolas Gonzalez Castro, Samuel K. McBrayer, Michael Weller, Timothy F. Cloughesy, Jana Portnow, Ovidiu C. Andronesi, Jill S. Barnholtz‐Sloan, Brigitta G. Baumert, Mitchel S. Berger, Wenya Linda Bi, Ranjit S. Bindra, Daniel P. Cahill, Susan M. Chang, J Costello, Craig Horbinski, Raymond Y. Huang, Robert B. Jenkins, Keith L. Ligon, Ingo K. Mellinghoff, Burt Nabors, Michael Platten, David A. Reardon, Diana D. Shi, David Schiff, Wolfgang Wick, Hai Yan, Andreas von Deimling, Martin J. van den Bent, William G. Kaelin, Patrick Y. Wen - Neuro-Oncology 2022 被引用: 237

  6. Targeting the HIF2–VEGF axis in renal cell carcinoma

    著者: Toni K. Choueiri, William G. Kaelin - Nature Medicine 2020 被引用: 476

  7. Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

    著者: Samuel K. McBrayer, Jared R. Mayers, Gabriel J. DiNatale, Diana D. Shi, Januka Khanal, Abhishek A. Chakraborty, Kristopher A. Sarosiek, Kimberly J. Briggs, Alissa K. Robbins, Tomasz Sewastianik, Sarah J. Shareef, Benjamin A. Olenchock, Seth J. Parker, Kensuke Tateishi, Jessica B. Spinelli, Mirazul Islam, Marcia C. Haigis, Ryan Looper, Keith L. Ligon, B Bernstein, Ruben D. Carrasco, Daniel P. Cahill, John M. Asara, Christian M. Metallo, Neela H. Yennawar, Matthew G. Vander Heiden, William G. Kaelin - Cell 2018 被引用: 374

  8. Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

    著者: Abhishek A. Chakraborty, Tuomas Laukka, Matti Myllykoski, Alison E. Ringel, Matthew A. Booker, Michael Tolstorukov, Yuzhong Jeff Meng, Samuel R. Meier, Rebecca B. Jennings, Amanda L. Creech, Zachary T. Herbert, Samuel K. McBrayer, Benjamin A. Olenchock, Jacob D. Jaffe, Marcia C. Haigis, Rameen Beroukhim, Sabina Signoretti, Peppi Koivunen, William G. Kaelin - Science 2019 被引用: 435

  9. On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models

    著者: Hyejin Cho, Xinlin Du, James P. Rizzi, Ella Liberzon, Abhishek A. Chakraborty, Wenhua Gao, Ingrid Carvo, Sabina Signoretti, Richard K. Bruick, John A. Josey, Eli M. Wallace, William G. Kaelin - Nature 2016 被引用: 461

  10. Influence of Metabolism on Epigenetics and Disease

    著者: William G. Kaelin, Steven L. McKnight - Cell 2013 被引用: 903

  11. 2-Oxoglutarate-dependent dioxygenases in cancer

    著者: Julie-Aurore Losman, Peppi Koivunen, William G. Kaelin - Nature reviews. Cancer 2020 被引用: 213

  12. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

    著者: James Brugarolas, Kui Lei, Rebecca L. Hurley, Brendan D. Manning, Jan H. Reiling, Ernst Hafen, Lee A. Witters, Leif W. Ellisen, William G. Kaelin - Genes & Development 2004 被引用: 1,376

  13. Von Hippel–Lindau disease: insights into oxygen sensing, protein degradation, and cancer

    著者: William G. Kaelin - Journal of Clinical Investigation 2022 被引用: 151

  14. The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks

    著者: Mircea Ivan, William G. Kaelin - Molecular Cell 2017 被引用: 275

  15. Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

    著者: Michael Ohh, Cheol Won Park, Mircea Ivan, Michael A. Hoffman, Tae‐You Kim, Eric Huang, Nikola P. Pavletich, Vincent Chau, William G. Kaelin - Nature Cell Biology 2000 被引用: 1,589

  16. Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

    著者: Peppi Koivunen, Sung-Woo Lee, Christopher G. Duncan, Giselle Y. López, Gang Lü, Shakti Ramkissoon, Julie A. Losman, Päivi Joensuu, Ulrich Bergmann, Stefan Größ, Jeremy Travins, Samuel Weiss, Ryan Looper, Keith L. Ligon, Roel G.W. Verhaak, Hai Yan, William G. Kaelin - Nature 2012 被引用: 729

  17. Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling

    著者: Jung-Hyun Min, Haifeng Yang, Mircea Ivan, Frank B. Gertler, William G. Kaelin, Nikola P. Pavletich - Science 2002 被引用: 773

  18. ( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

    著者: Julie-Aurore Losman, Ryan Looper, Peppi Koivunen, Sung-Woo Lee, Rebekka K. Schneider, Christine M. McMahon, Glenn S. Cowley, David E. Root, Benjamin L. Ebert, William G. Kaelin - Science 2013 被引用: 711

  19. De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

    著者: Diana D. Shi, Milan R. Savani, Michael M. Levitt, Adam C. Wang, Jennifer E. Endress, Cylaina Bird, Joseph Buehler, Sylwia A. Stopka, Michael S. Regan, Yu‐Fen Lin, Vinesh T. Puliyappadamba, Wenhua Gao, Januka Khanal, Laura Evans, J Lee, Lei Guo, Yi Xiao, Min Xu, Bofu Huang, Rebecca B. Jennings, Dennis M. Bonal, Misty S. Martin-Sandoval, Tammie Dang, Lauren C. Gattie, Amy Cameron, Sung-Woo Lee, John M. Asara, Harley I. Kornblum, Tak W. Mak, Ryan Looper, Quang‐Dé Nguyen, Sabina Signoretti, Stefan Gradl, Andreas Sutter, Michael Jeffers, Andreas Janzer, Mark A. Lehrman, Lauren G. Zacharias, Thomas P. Mathews, Julie-Aurore Losman, Timothy E. Richardson, Daniel P. Cahill, Ralph J. DeBerardinis, Keith L. Ligon, Lin Xu, Peter Ly, Nathalie Y.R. Agar, Kalil G. Abdullah, Isaac S. Harris, William G. Kaelin, Samuel K. McBrayer - Cancer Cell 2022 被引用: 129

  20. The VHL/HIF axis in clear cell renal carcinoma

    著者: Chuan Shen, William G. Kaelin - Seminars in Cancer Biology 2012 被引用: 385

  21. Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival

    著者: Matthew G. Oser, Raquel Fonseca, Abhishek A. Chakraborty, Rachel Brough, Alexander Spektor, Rebecca B. Jennings, Abdallah Flaifel, Jesse Novak, Aditi Gulati, Elizabeth Buss, Scott T. Younger, Samuel K. McBrayer, Glenn S. Cowley, Dennis M. Bonal, Quang-Dé Nguyen, Laura Brullé-Soumaré, Paula Taylor, Stefano Cairo, Colm J. Ryan, Elizabeth J. Pease, Kim Maratea, Jon Travers, David E. Root, Sabina Signoretti, David Pellman, Susan Ashton, Christopher J. Lord, Simon T. Barry, William G. Kaelin - Cancer Discovery 2018 被引用: 176

  22. The Concept of Synthetic Lethality in the Context of Anticancer Therapy

    著者: William G. Kaelin - Nature reviews. Cancer 2005 被引用: 1,394

  23. Mitochondrial remodeling and ischemic protection by G protein–coupled receptor 35 agonists

    著者: Gregory A. Wyant, Wenyu Yu, IIias P. Doulamis, Rio S. Nomoto, Mossab Y. Saeed, Thomas Duignan, James D. McCully, William G. Kaelin - Science 2022 被引用: 107

  24. Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes

    著者: Tuomas Laukka, Christopher J. Mariani, Tuukka Ihantola, John Z. Cao, Juho Hokkanen, William G. Kaelin, Lucy A. Godley, Peppi Koivunen - Journal of Biological Chemistry 2015 被引用: 302