Peter J. Ratcliffe
1984–2025 年に発表
- 206
- 論文数
- 72,553
- 被引用数
- 124
- h 指数
- 201
- i10 指数
被引用数
引用元
国・地域
機関
分野
- Biochemistry, Genetics and Molecular Biology61%
- Medicine27.9%
- Immunology and Microbiology4%
- Neuroscience1.6%
- Engineering1.3%
- Environmental Science0.9%
- その他3.3%
トピック
- Cancer, Hypoxia, and Metabolism14.2%
- Epigenetics and DNA Methylation2.9%
- Mitochondrial Function and Pathology2.7%
- RNA modifications and cancer2.7%
- Angiogenesis and VEGF in Cancer2.3%
- High Altitude and Hypoxia2.2%
- その他73%
共著者
- Christopher W. Pugh67
- Patrick H. Maxwell42
- Christopher J. Schofield35
- David R. Mole31
- Adrian L. Harris28
- Jonathan Gleadle18
- Matthew E. Cockman16
- Ya‐Min Tian16
- Johannes Schödel14
- Norma Masson14
- Peter A. Robbins14
- Tammie Bishop13
- Kai‐Uwe Eckardt12
- Benedikt M. Kessler11
- Charles C. Wykoff11
- M.A. McDonough11
- Patrick J. Pollard11
- Kirsty S. Hewitson10
- Mathew L. Coleman10
- Hani Choudhry9
- Rasheduzzaman Chowdhury9
- Jaromı́r Pastorek8
- Julie Adam8
- Anthony Tumber7
全論文
- Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
著者: William G. Kaelin, Peter J. Ratcliffe - Molecular Cell 2008 被引用: 3,236
- Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
著者: Panu Jaakkola, David R. Mole, Ya‐Min Tian, Michael Wilson, Adriana Gielbert, Simon J. Gaskell, Alex von Kriegsheim, Holger Hebestreit, Mridul Mukherji, Christopher J. Schofield, Patrick H. Maxwell, Christopher W. Pugh, Peter J. Ratcliffe - Science 2001 被引用: 5,538
- The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
著者: Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang, Steven C. Clifford, Emma C. Vaux, Matthew E. Cockman, Charles C. Wykoff, Christopher W. Pugh, Eamonn R. Maher, Peter J. Ratcliffe - Nature 1999 被引用: 5,225
- C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
著者: Andrew Epstein, Jonathan Gleadle, Luke A. McNeill, Kirsty S. Hewitson, John P. O’Rourke, David R. Mole, Mridul Mukherji, Eric Metzen, Michael Wilson, Anu Dhanda, Ya‐Min Tian, Norma Masson, Donald L. Hamilton, Panu Jaakkola, Robert Barstead, Jonathan Hodgkin, Patrick H. Maxwell, Christopher W. Pugh, Christopher J. Schofield, Peter J. Ratcliffe - Cell 2001 被引用: 3,353
- Regulation of angiogenesis by hypoxia: role of the HIF system
著者: Christopher W. Pugh, Peter J. Ratcliffe - Nature Medicine 2003 被引用: 2,511
- Oxygen sensing by HIF hydroxylases
著者: Christopher J. Schofield, Peter J. Ratcliffe - Nature Reviews Molecular Cell Biology 2004 被引用: 2,036
- Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
著者: Peter Carmeliet, Yuval Dor, Jean-Marc Herbert, Dai Fukumura, Koen Brusselmans, Mieke Dewerchin, Michal Neeman, Françoise Bono, Rinat Abramovitch, Patrick H. Maxwell, Cameron J. Koch, Peter J. Ratcliffe, Lieve Moons, Rakesh K. Jain, Désiré Collen, Eli Keshet - Nature 1998 被引用: 2,505
- Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
著者: Wai‐Ching Hon, Michael Wilson, Karl Harlos, Timothy D. W. Claridge, Christopher J. Schofield, Christopher W. Pugh, Patrick H. Maxwell, Peter J. Ratcliffe, David I. Stuart, E. Yvonne Jones - Nature 2002 被引用: 753
- The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases
著者: Rasheduzzaman Chowdhury, Kar Kheng Yeoh, Ya‐Min Tian, Lars Hillringhaus, Eleanor A. L. Bagg, Nathan R. Rose, Ivanhoe K. H. Leung, Xuan S Li, Esther C. Y. Woon, Ming Yang, M.A. McDonough, Oliver N. F. King, I.J. Clifton, Robert J. Klose, Timothy D. W. Claridge, Peter J. Ratcliffe, Christopher J. Schofield, Akane Kawamura - EMBO Reports 2011 被引用: 1,031
- Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling
著者: Julie Adam, Emine Hatipoglu, Linda O′Flaherty, Nicola Ternette, Natasha Sahgal, Helen Lockstone, Dilair Baban, Emma Nye, Gordon Stamp, Kathryn Wolhuter, Marcus Stevens, Román Fischer, Peter Carmeliet, Patrick H. Maxwell, Christopher W. Pugh, Norma Frizzell, Tomoyoshi Soga, Benedikt M. Kessler, Mona El‐Bahrawy, Peter J. Ratcliffe, Patrick J. Pollard - Cancer Cell 2011 被引用: 578
- Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor
著者: Rebecca J. Appelhoff, Ya‐Min Tian, Raju R. Raval, Helen Turley, Adrian L. Harris, Christopher W. Pugh, Peter J. Ratcliffe, Jonathan Gleadle - Journal of Biological Chemistry 2004 被引用: 1,106
- HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors.
著者: Heidi Sowter, Peter J. Ratcliffe, Peter H. Watson, Arnold H. Greenberg, Adrian L. Harris - 2001 被引用: 717
- Mechanisms of hypoxia signalling: new implications for nephrology
著者: Johannes Schödel, Peter J. Ratcliffe - Nature Reviews Nephrology 2019 被引用: 326
- Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer
著者: Johannes Schödel, Steffen Grampp, Eamonn R. Maher, Holger Moch, Peter J. Ratcliffe, Paul Russo, David R. Mole - European Urology 2015 被引用: 423
- Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
著者: Norma Masson, Thomas P. Keeley, Beatrice Giuntoli, Mark D. White, Mikel Lavilla-Puerta, Pierdomenico Perata, Richard J. Hopkinson, Emily Flashman, Francesco Licausi, Peter J. Ratcliffe - Science 2019 被引用: 231
- HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
著者: Jennifer S. Isaacs, Yun Jin Jung, David R. Mole, Sunmin Lee, Carlos A. Torres‐Cabala, Yuen‐Li Chung, Maria J. Merino, Jane B. Trepel, Berton Zbar, Jorge R. Toro, Peter J. Ratcliffe, W. Marston Linehan, Len Neckers - Cancer Cell 2005 被引用: 942
- High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq
著者: Johannes Schödel, Spyros Oikonomopoulos, Jiannis Ragoussis, Christopher W. Pugh, Peter J. Ratcliffe, David R. Mole - Blood 2011 被引用: 734
- Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation
著者: Ananda S. Mirchandani, Stephen J. Jenkins, Calum C. Bain, Manuel A. Sánchez-García, Hannah Lawson, Patrícia Coelho, Fiona Murphy, David Griffith, Ailiang Zhang, Tyler Morrison, Tony Ly, Simone Arienti, Pranvera Sadiku, Emily Watts, Rebecca Dickinson, Leila Reyes, George Cooper, Sarah A. Clark, David Lewis, Van Kelly, Christos Spanos, Kathryn Musgrave, Liam Delaney, I. Harper, Jonathan Scott, Nick Parkinson, Anthony Rostron, J. Kenneth Baillie, Sara Clohisey, Clare Pridans, Lara Campana, Philip Starkey Lewis, A. John Simpson, David H. Dockrell, Jürgen Schwarze, Nikhil Hirani, Peter J. Ratcliffe, Christopher W. Pugh, Kamil R. Kranc, Stuart J. Forbes, Moira K. B. Whyte, Sarah R. Walmsley - Nature Immunology 2022 被引用: 80
- The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages
著者: Katherine Louise Talks, Helen Turley, Kevin C. Gatter, Patrick H. Maxwell, Christopher W. Pugh, Peter J. Ratcliffe, Adrian L. Harris - American Journal Of Pathology 2000 被引用: 1,303
- Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization
著者: Massimiliano Mazzone, Daniela Dettori, Rodrigo Leite de Oliveira, Sonja Loges, Thomas Schmidt, Bart Jonckx, Ya-Min Tian, Anthony A. Lanahan, Patrick J. Pollard, Carmen Ruiz de Almodóvar, Frederik De Smet, Stefan Vinckier, Julián Aragonés, Koen Debackere, Aernout Luttun, Sabine Wyns, Bénédicte F. Jordan, Alberto Pisacane, Bernard Gallez, Maria Grazia Lampugnani, Elisabetta Dejana, Michael Simons, Peter J. Ratcliffe, Patrick H. Maxwell, Peter Carmeliet - Cell 2009 被引用: 816
- Widespread, hypoxia‐inducible expression of HIF‐2α in distinct cell populations of different organs
著者: Michael S. Wiesener, Jan Steffen Jürgensen, Christian Rosenberger, Charlotte Scholze, Jan Hörstrup, Christina Warnecke, Stefano J. Mandriota, Ingo Bechmann, Ulrich Frei, Christopher W. Pugh, Peter J. Ratcliffe, Sebastian Bachmann, Patrick H. Maxwell, Kai‐Uwe Eckardt - The FASEB Journal 2002 被引用: 734
- Hypoxia-inducible expression of tumor-associated carbonic anhydrases.
著者: Charles C. Wykoff, Nigel Beasley, Peter H. Watson, Kevin Turner, Jaromı́r Pastorek, Amen Sibtain, George D. Wilson, Helen Turley, Kate Talks, Patrick H. Maxwell, Christopher W. Pugh, Peter J. Ratcliffe, Adrian L. Harris - 2000 被引用: 1,284
- Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts
著者: David R. Mole, Christine Blancher, Richard R. Copley, Patrick J. Pollard, Jonathan Gleadle, Jiannis Ragoussis, Peter J. Ratcliffe - Journal of Biological Chemistry 2009 被引用: 550
- Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma
著者: Raju R. Raval, Kah Weng Lau, Maxine Tran, Heidi Sowter, Stefano J. Mandriota, Jiliang Li, Christopher W. Pugh, Patrick H. Maxwell, Adrian L. Harris, Peter J. Ratcliffe - Molecular and Cellular Biology 2005 被引用: 933
