Len Neckers
1976–2024 年に発表
- 132
- 論文数
- 29,035
- 被引用数
- 95
- h 指数
- 132
- i10 指数
被引用数
引用元
国・地域
機関
分野
- Biochemistry, Genetics and Molecular Biology64.9%
- Medicine23.2%
- Immunology and Microbiology4.6%
- Neuroscience2.3%
- Computer Science1%
- Chemistry1%
- その他3%
トピック
- Heat shock proteins research10.5%
- Cancer, Hypoxia, and Metabolism3.8%
- Endoplasmic Reticulum Stress and Disease3.3%
- Computational Drug Discovery Methods3%
- Ubiquitin and proteasome pathways2.4%
- ATP Synthase and ATPases Research2.2%
- その他74.8%
共著者
- Jane B. Trepel32
- Wanping Xu20
- Kristin Beebe19
- Edward G. Mimnaugh14
- Mehdi Mollapour14
- Shinji Tsutsumi12
- Sunmin Lee11
- W. Marston Linehan11
- Min-Jung Lee10
- Bradley T. Scroggins9
- Chrisostomos Prodromou8
- Carole Sourbier7
- Jennifer S. Isaacs7
- Luke Whitesell7
- Barry Panaretou6
- Brian S. J. Blagg6
- Gennady Bratslavsky6
- Maria J. Merino6
- Mikhail V. Blagosklonny6
- Monica G. Marcu6
- Ramaprasad Srinivasan6
- Thomas L. Prince6
- Xitong Yuan6
- Cathy D. Vocke5
全論文
- Targeting the dynamic HSP90 complex in cancer
著者: Jane B. Trepel, Mehdi Mollapour, Giuseppe Giaccone, Len Neckers - Nature reviews. Cancer 2010 被引用: 1,528
- Structural and functional complexity of HSP90 in cellular homeostasis and disease
著者: Gabriela Chiosis, Chander Singh Digwal, Jane B. Trepel, Len Neckers - Nature Reviews Molecular Cell Biology 2023 被引用: 204
- Regulation and function of the human HSP90AA1 gene
著者: Abbey D. Zuehlke, Kristin Beebe, Len Neckers, Thomas L. Prince - Gene 2015 被引用: 353
- HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
著者: Jennifer S. Isaacs, Yun Jin Jung, David R. Mole, Sunmin Lee, Carlos A. Torres‐Cabala, Yuen‐Li Chung, Maria J. Merino, Jane B. Trepel, Berton Zbar, Jorge R. Toro, Peter J. Ratcliffe, W. Marston Linehan, Len Neckers - Cancer Cell 2005 被引用: 942
- Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?
著者: Len Neckers, Paul Workman - Clinical Cancer Research 2012 被引用: 903
- An update on the status of HSP90 inhibitors in cancer clinical trials
著者: Shraddha Rastogi, Abhinav Joshi, Nahoko Sato, Sunmin Lee, Min-Jung Lee, Jane B. Trepel, Len Neckers - Cell Stress and Chaperones 2024 被引用: 103
- The Therapeutic Target Hsp90 and Cancer Hallmarks
著者: Yoshihiko Miyata, Hitoshi Nakamoto, Len Neckers - Current Pharmaceutical Design 2012 被引用: 343
- Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.
著者: Luke Whitesell, Edward G. Mimnaugh, B. de Costa, Catherine E. Myers, Len Neckers - National Academy of Sciences, Proceedings of the National Academy of Sciences 1994 被引用: 1,446
- HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation
著者: Toshiki Kijima, Thomas L. Prince, Megan L. Tigue, Kendrick Yim, Harvey Schwartz, Kristin Beebe, Sunmin Lee, Marek A. Budzyński, Heinric Williams, Jane B. Trepel, Lea Sistonen, Stuart K. Calderwood, Len Neckers - Scientific Reports 2018 被引用: 148
- Drugging the Cancer Chaperone HSP90
著者: Paul Workman, Francis Burrows, Len Neckers, Neal Rosen - Annals of the New York Academy of Sciences 2007 被引用: 522
- Update on Hsp90 Inhibitors in Clinical Trial
著者: Yoonhee Kim, S. Alarcon, S. Lee, M.-J. Lee, Giuseppe Giaccone, Len Neckers, Jane B. Trepel - Current Topics in Medicinal Chemistry 2009 被引用: 307
- Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90
著者: Byoung Heon Kang, Janet Plescia, Ho Young Song, Massimiliano Meli, Giorgio Colombo, Kristin Beebe, Bradley T. Scroggins, Len Neckers, Dario C. Altieri - Journal of Clinical Investigation 2009 被引用: 242
- An Acetylation Site in the Middle Domain of Hsp90 Regulates Chaperone Function
著者: Bradley T. Scroggins, Kenneth Robzyk, Dongxia Wang, Monica G. Marcu, Shinji Tsutsumi, Kristin Beebe, Robert J. Cotter, Sara J. Felts, David O. Toft, Larry M. Karnitz, Neal Rosen, Len Neckers - Molecular Cell 2007 被引用: 411
- IL‐1β mediated up‐regulation of HIF‐lα via an NFkB/COX‐2 pathway identifies HIF‐1 as a critical link between inflammation and oncogenesis
著者: Yunjin Jung, Jennifer S. Isaacs, Sunmin Lee, Jane B. Trepel, Len Neckers - The FASEB Journal 2003 被引用: 675
- Functional proteomic screens reveal an essential extracellular role for hsp90α in cancer cell invasiveness
著者: Brenda K. Eustace, Takashi Sakurai, Jean K. Stewart, Dean Yimlamai, Christine Unger, Carol Zehetmeier, Blanca Lain, Claudia Torella, Stefan Henning, Gerald Beste, Bradley T. Scroggins, Len Neckers, Leodevico L. Ilag, Daniel G. Jay - Nature Cell Biology 2004 被引用: 595
- Curcumin is an Inhibitor of p300 Histone Acetylatransferase
著者: Len Neckers, Jane B. Trepel, Sunmin Lee, Eun-Joo Chung, Min-Jung Lee, Yunjin Jung, Monica G. Marcu - Medicinal Chemistry 2006 被引用: 307
- Post-translational modifications of Hsp90 and their contributions to chaperone regulation
著者: Mehdi Mollapour, Len Neckers - Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2011 被引用: 290
- Asymmetric Hsp90 N Domain SUMOylation Recruits Aha1 and ATP-Competitive Inhibitors
著者: Mehdi Mollapour, Dimitra Bourboulia, Kristin Beebe, Mark R. Woodford, Sigrun Polier, Anthony Hoang, Raju Chelluri, Yu Li, Ailan Guo, Min-Jung Lee, Elham Fotooh‐Abadi, Sahar Khan, Thomas L. Prince, Naoto Miyajima, Soichiro Yoshida, Shinji Tsutsumi, Wanping Xu, Barry Panaretou, William G. Stetler‐Stevenson, Gennady Bratslavsky, Jane B. Trepel, Chrisostomos Prodromou, Len Neckers - Molecular Cell 2014 被引用: 130
- Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development
著者: Len Neckers, Brian S. J. Blagg, Timothy Haystead, Jane B. Trepel, Luke Whitesell, Didier Picard - Cell Stress and Chaperones 2018 被引用: 128
- Swe1Wee1-Dependent Tyrosine Phosphorylation of Hsp90 Regulates Distinct Facets of Chaperone Function
著者: Mehdi Mollapour, Shinji Tsutsumi, Alison C. Donnelly, Kristin Beebe, Mari Tokita, Min-Jung Lee, Sunmin Lee, Giulia Morra, Dimitra Bourboulia, Bradley T. Scroggins, Giorgio Colombo, Brian S. J. Blagg, Barry Panaretou, William G. Stetler‐Stevenson, Jane B. Trepel, Peter W. Piper, Chrisostomos Prodromou, Laurence H. Pearl, Len Neckers - Molecular Cell 2010 被引用: 195
- Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein–Protein Interactions with Heat Shock Protein 70 (Hsp70)
著者: Hao Shao, Xiaokai Li, Michael A. Moses, Luke A. Gilbert, Chakrapani Kalyanaraman, Zapporah T. Young, Margarita Chernova, Sara N. Journey, Jonathan S. Weissman, Byron Hann, Matthew P. Jacobson, Len Neckers, Jason E. Gestwicki - Journal of Medicinal Chemistry 2018 被引用: 120
- Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu
著者: Wanping Xu, Monica G. Marcu, Xitong Yuan, Edward G. Mimnaugh, Cam Patterson, Len Neckers - National Academy of Sciences, Proceedings of the National Academy of Sciences 2002 被引用: 430
- Hsp90 inhibitors as novel cancer chemotherapeutic agents
著者: Len Neckers - Trends in Molecular Medicine 2002 被引用: 674
- Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells
著者: Andrea Rasola, Len Neckers, Didier Picard - Trends in Cell Biology 2014 被引用: 140
