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Graeme C.M. Smith

1989–2024 年に発表

別表記
Graeme C. M. Smith
51
論文数
20,948
被引用数
46
h 指数
51
i10 指数

被引用数

Graeme C.M. Smith の年別被引用数1982 年: 被引用 1 件1990 年: 被引用 1 件1991 年: 被引用 2 件1992 年: 被引用 2 件1993 年: 被引用 4 件1994 年: 被引用 3 件1995 年: 被引用 26 件1996 年: 被引用 89 件1997 年: 被引用 91 件1998 年: 被引用 92 件1999 年: 被引用 96 件2000 年: 被引用 107 件2001 年: 被引用 110 件2002 年: 被引用 90 件2003 年: 被引用 84 件2004 年: 被引用 114 件2005 年: 被引用 149 件2006 年: 被引用 208 件2007 年: 被引用 230 件2008 年: 被引用 260 件2009 年: 被引用 262 件2010 年: 被引用 348 件2011 年: 被引用 321 件2012 年: 被引用 319 件2013 年: 被引用 308 件2014 年: 被引用 282 件2015 年: 被引用 269 件2016 年: 被引用 238 件2017 年: 被引用 245 件2018 年: 被引用 190 件2019 年: 被引用 595 件2020 年: 被引用 661 件2021 年: 被引用 577 件2022 年: 被引用 450 件2023 年: 被引用 346 件2024 年: 被引用 544 件2025 年: 被引用 247 件2026 年: 被引用 2 件1983〜1989 年は被引用が無いため表示していません

引用元

国・地域

この著者を引用した国・地域の世界地図アメリカ合衆国: 引用元論文 2,952 件、この内訳の 30.8%イギリス: 引用元論文 1,182 件、この内訳の 12.3%中国: 引用元論文 726 件、この内訳の 7.6%ドイツ: 引用元論文 431 件、この内訳の 4.5%カナダ: 引用元論文 425 件、この内訳の 4.4%イタリア: 引用元論文 395 件、この内訳の 4.1%フランス: 引用元論文 372 件、この内訳の 3.9%日本: 引用元論文 274 件、この内訳の 2.9%オランダ: 引用元論文 268 件、この内訳の 2.8%スペイン: 引用元論文 236 件、この内訳の 2.5%オーストラリア: 引用元論文 232 件、この内訳の 2.4%スイス: 引用元論文 202 件、この内訳の 2.1%
0%30.8%その他 19.7%

機関

分野

  • Biochemistry, Genetics and Molecular Biology53.4%
  • Medicine40.7%
  • Immunology and Microbiology2.4%
  • Pharmacology, Toxicology and Pharmaceutics1%
  • Chemistry0.6%
  • Computer Science0.5%
  • その他1.4%

トピック

  • DNA Repair Mechanisms16.8%
  • PARP inhibition in cancer therapy12.4%
  • CRISPR and Genetic Engineering4.8%
  • Cancer-related Molecular Pathways4.1%
  • BRCA gene mutations in cancer2.4%
  • Cancer therapeutics and mechanisms2%
  • その他57.5%

共著者

全論文

検索で開く
  1. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

    著者: Hannah Farmer, Nuala McCabe, Christopher J. Lord, Andrew Tutt, Damian A. Johnson, Tobias B. Richardson, Manuela Santarosa, Krystyna J. Dillon, Ian Hickson, Charlotte Knights, Niall M.B. Martin, Stephen P. Jackson, Graeme C.M. Smith, Alan Ashworth - Nature 2005 被引用: 6,735

  2. Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance

    著者: Diana Zatreanu, Helen M.R. Robinson, Omar Alkhatib, Marie Boursier, Harry Finch, Lerin Geo, Diego Grande, Vera Grinkevich, Robert A. Heald, Sophie Langdon, Jayesh B. Majithiya, Claire McWhirter, Niall M.B. Martin, Shaun Moore, Joana Neves, Eeson Rajendra, Marco Ranzani, Theresia A. Schaedler, Martin L. Stockley, Kimberley A. Wiggins, Rachel Brough, Sandhya Sridhar, Aditi Gulati, Nan Shao, Luned Badder, Daniela Novo, Eleanor Knight, Rebecca Marlow, Syed Haider, Elsa Callén, Graeme Hewitt, Joost Schimmel, Remko Prevo, Christina Alli, Amanda Ferdinand, Cameron Bell, Peter Blencowe, Christopher Bot, Mathew Calder, Mark Charles, Jayne Curry, Tennyson Ekwuru, Katherine Ewings, Wojciech Krajewski, Ellen MacDonald, Hollie McCarron, Leon Pang, Chris Pedder, Laurent Rigoreau, Martin E. Swarbrick, Ed Wheatley, Simon N. Willis, Ai Ching Wong, André Nussenzweig, Marcel Tijsterman, Andrew Tutt, Simon J. Boulton, Geoff S. Higgins, Stephen J. Pettitt, Graeme C.M. Smith, Christopher J. Lord - Nature Communications 2021 被引用: 350

  3. POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells

    著者: Ondrej Beláň, Marie Sebald, Marek Adamowicz, Roopesh Anand, Aleksandra Vančevska, Joana Neves, Vera Grinkevich, Graeme Hewitt, Sandra Segura‐Bayona, Roberto Bellelli, Helen M.R. Robinson, Geoff S. Higgins, Graeme C.M. Smith, Stephen C. West, David Rueda, Simon J. Boulton - Molecular Cell 2022 被引用: 129

  4. AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity

    著者: Christine M. Chresta, Barry R. Davies, Ian Hickson, Tom Harding, Sabina Cosulich, Susan E. Critchlow, John P. Vincent, Rebecca Ellston, Darren Jones, Patrizia Sini, Dominic I. James, Zoë Howard, Phillippa Dudley, Gareth Hughes, Lisa M. Smith, Sharon Maguire, Marc Hummersone, Karine Malagu, Keith Menear, Richard O. Jenkins, Matt Jacobsen, Graeme C.M. Smith, Sylvie M. Guichard, Martin Pass - Cancer Research 2009 被引用: 795

  5. Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition

    著者: Nuala McCabe, Nicholas C. Turner, Christopher J. Lord, Katarzyna Kluzek, Aneta Białkowska, Sally Swift, Sabrina Giavara, Mark J. O’Connor, Andrew Tutt, Małgorzata Z. Zdzienicka, Graeme C.M. Smith, Alan Ashworth - Cancer Research 2006 被引用: 1,305

  6. Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM

    著者: Ian Hickson, Yan Zhao, Caroline J. Richardson, Sharon J. Green, Niall M.B. Martin, Alisdair I. Orr, Philip M. Reaper, Stephen P. Jackson, Nicola J. Curtin, Graeme C.M. Smith - Cancer Research 2004 被引用: 1,210

  7. 4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1

    著者: Keith Menear, Claire Adcock, Robert Boulter, Xiaoling Cockcroft, Louise Copsey, Aaron Cranston, Krystyna J. Dillon, Jan Drzewiecki, Sheila Garman, Sylvie Gomez, Hashim Javaid, Frank Kerrigan, Charlotte Knights, Alan Lau, Vincent M. Loh, Ian T.W. Matthews, Stephen Moore, Mark J. O’Connor, Graeme C.M. Smith, Niall M.B. Martin - Journal of Medicinal Chemistry 2008 被引用: 586

  8. Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps

    著者: Mariana Paes Dias, Vivek Tripathi, Ingrid van der Heijden, Ke Cong, Eleni-Maria Manolika, Jinhyuk Bhin, Ewa Gogola, Panagiotis Galanos, Stefano Annunziato, Cor Lieftink, Miguel Andújar, Sanjiban Chakrabarty, Graeme C.M. Smith, Marieke van de Ven, Roderick L. Beijersbergen, Jiřina Bártková, Sven Rottenberg, Sharon B. Cantor, Jiří Bártek, Arnab Ray Chaudhuri, Jos Jonkers - Molecular Cell 2021 被引用: 93

  9. Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically

    著者: Lucy C. Riches, Antonio G. Trinidad, Gareth Hughes, Gemma N. Jones, Adina Hughes, Andrew Thomason, Paul R. Gavine, Andy Cui, Stephanie Ling, Jonathan Stott, Roger Clark, S Peel, Pendeep Gill, Louise Goodwin, Aaron Smith, Kurt G. Pike, Bernard Barlaam, Martin Pass, Mark J. O’Connor, Graeme C.M. Smith, Elaine Cadogan - Molecular Cancer Therapeutics 2019 被引用: 160

  10. Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries

    著者: Justin J. J. Leahy, Bernard T. Golding, Roger J. Griffin, Ian R. Hardcastle, Caroline J. Richardson, Laurent Rigoreau, Graeme C.M. Smith - Bioorganic & Medicinal Chemistry Letters 2004 被引用: 407

  11. Modulating mutational outcomes and improving precise gene editing at CRISPR-Cas9-induced breaks by chemical inhibition of end-joining pathways

    著者: Joost Schimmel, Núria Muñoz-Subirana, Hanneke Kool, Robin van Schendel, Sven van der Vlies, Juliette A. Kamp, Femke M.S. de Vrij, Steven A. Kushner, Graeme C.M. Smith, Simon J. Boulton, Marcel Tijsterman - Cell Reports 2023 被引用: 73

  12. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

    著者: Ali Jazayeri, Jacob Falck, Claudia Lukas, Jiří Bártek, Graeme C.M. Smith, Jiri Lukas, Stephen P. Jackson - Nature Cell Biology 2005 被引用: 1,049

  13. Preclinical Evaluation of a Potent Novel DNA-Dependent Protein Kinase Inhibitor NU7441

    著者: Yan Zhao, Huw D. Thomas, Michael A. Batey, Ian G. Cowell, Caroline J. Richardson, Roger J. Griffin, A H Calvert, David R. Newell, Graeme C.M. Smith, Nicola J. Curtin - Cancer Research 2006 被引用: 447

  14. Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta

    著者: Martin L. Stockley, Amanda Ferdinand, Giovanni Benedetti, Peter Blencowe, Susan M. Boyd, Mat Calder, Mark Charles, Lucy V. Edwardes, Tennyson Ekwuru, Harry Finch, Alessandro Galbiati, Lerin Geo, Diego Grande, Vera Grinkevich, Nicholas D. Holliday, Wojciech Krajewski, Ellen MacDonald, Jayesh B. Majithiya, Hollie McCarron, Claire McWhirter, Viral Patel, Chris Pedder, Eeson Rajendra, Marco Ranzani, Laurent Rigoreau, Helen M.R. Robinson, Theresia A. Schaedler, Julija Sirina, Graeme C.M. Smith, Martin E. Swarbrick, A.P. Turnbull, Simon N. Willis, Robert A. Heald - Journal of Medicinal Chemistry 2022 被引用: 43

  15. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation

    著者: T Blunt, Nicholas Finnie, Guillermo E. Taccioli, Graeme C.M. Smith, Jocelyne Demengeot, Tanya Gottlieb, Ryushin Mizuta, A. J. Varghese, Frederick W. Alt, Penny A. Jeggo, Stephen P. Jackson - Cell 1995 被引用: 866

  16. A Pathway of Double-Strand Break Rejoining Dependent upon ATM, Artemis, and Proteins Locating to γ-H2AX Foci

    著者: Enriqueta Riballo, Martin Kühne, Nicole Rief, Aidan J. Doherty, Graeme C.M. Smith, María J. Recio, Caroline Reis, Kirsten Dahm, Andreas Fricke, Andrea Krempler, Antony R. Parker, Stephen P. Jackson, Andrew R. Gennery, Penny A. Jeggo, Markus Löbrich - Molecular Cell 2004 被引用: 832

  17. Selective Inhibition of BRCA2-Deficient Mammary Tumor Cell Growth by AZD2281 and Cisplatin

    著者: Bastiaan Evers, Rinske Drost, Eva Schut, Michiel de Bruin, Eline van der Burg, Patrick W.B. Derksen, Henne Holstege, Xiaoling Liu, Ellen van Drunen, H. Berna Beverloo, Graeme C.M. Smith, Niall M.B. Martin, Alan Lau, Mark J. O’Connor, Jos Jonkers - Clinical Cancer Research 2008 被引用: 334

  18. Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models

    著者: Gonzalo Rodríguez‐Berriguete, Marco Ranzani, Remko Prevo, Rathi Puliyadi, Nicole Machado, Hannah R. Bolland, Val Millar, Daniel Ebner, Marie Boursier, Aurora Cerutti, Alessandro Cicconi, Alessandro Galbiati, Diego Grande, Vera Grinkevich, Jayesh B. Majithiya, Desirèe Piscitello, Eeson Rajendra, Martin L. Stockley, Simon J. Boulton, Ester M. Hammond, Robert A. Heald, Graeme C.M. Smith, Helen M.R. Robinson, Geoff S. Higgins - Clinical Cancer Research 2023 被引用: 34

  19. Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1.

    著者: Stephany Veuger, Nicola J. Curtin, Caroline J. Richardson, Graeme C.M. Smith, Barbara W. Durkacz - 2003 被引用: 331

  20. The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo

    著者: Victoria Weston, Ceri Oldreive, Anna Skowrońska, David Oscier, Guy Pratt, Martin J.S. Dyer, Graeme C.M. Smith, Judy E. Powell, Zbigniew Rudzki, Pamela Kearns, Paul Moss, A. Malcolm R. Taylor, Tatjana Stanković - Blood 2010 被引用: 305

  21. Exploiting the DNA Repair Defect in BRCA Mutant Cells in the Design of New Therapeutic Strategies for Cancer

    著者: Andrew Tutt, Christopher J. Lord, Nuala McCabe, Hannah Farmer, Nicholas C. Turner, Niall M.B. Martin, Stephen P. Jackson, Graeme C.M. Smith, Alan Ashworth - Cold Spring Harbor Symposia on Quantitative Biology 2005 被引用: 189

  22. Discovery of Potent Chromen-4-one Inhibitors of the DNA-Dependent Protein Kinase (DNA-PK) Using a Small-Molecule Library Approach

    著者: Ian R. Hardcastle, Xiaoling Cockcroft, Nicola J. Curtin, Marine Desage El-Murr, Justin J. J. Leahy, Martin L. Stockley, Bernard T. Golding, Laurent Rigoreau, Caroline J. Richardson, Graeme C.M. Smith, Roger J. Griffin - Journal of Medicinal Chemistry 2005 被引用: 170

  23. Chemosensitization of Cancer Cells by KU-0060648, a Dual Inhibitor of DNA-PK and PI-3K

    著者: Joanne M. Munck, Michael A. Batey, Yan Zhao, Helen Jenkins, Caroline J. Richardson, Céline Cano, Michele Tavecchio, Jody Barbeau, Julia Bárdos, Liam Cornell, Roger J. Griffin, Keith Menear, Andrew Slade, Pia Thömmes, Niall M.B. Martin, David R. Newell, Graeme C.M. Smith, Nicola J. Curtin - Molecular Cancer Therapeutics 2012 被引用: 131

  24. BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of poly (ADP-ribose) polymerase: An issue of potency

    著者: Nuala McCabe, Christopher J. Lord, Andrew Tutt, Niall M.B. Martin, Graeme C.M. Smith, Alan Ashworth - Cancer Biology & Therapy 2005 被引用: 151