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Huib Ovaa

Active 2002–2025

120
Papers
19,557
Citations
79
h-index
119
i10-index

Citations

Citations per year for Huib Ovaa1932: 1 citations1987: 8 citations1995: 2 citations2003: 20 citations2004: 41 citations2005: 50 citations2006: 104 citations2007: 129 citations2008: 132 citations2009: 157 citations2010: 138 citations2011: 149 citations2012: 187 citations2013: 179 citations2014: 217 citations2015: 172 citations2016: 220 citations2017: 223 citations2018: 204 citations2019: 691 citations2020: 1,014 citations2021: 1,123 citations2022: 886 citations2023: 684 citations2024: 891 citations2025: 382 citations2026: 13 citations1933–1986: no citations, so these years are not shown1988–1994: no citations, so these years are not shown1996–2002: no citations, so these years are not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 2,459 citing papers, 26.3% of this breakdownChina: 1,179 citing papers, 12.6% of this breakdownUnited Kingdom: 694 citing papers, 7.4% of this breakdownGermany: 652 citing papers, 7% of this breakdownNetherlands: 511 citing papers, 5.5% of this breakdownCanada: 290 citing papers, 3.1% of this breakdownFrance: 266 citing papers, 2.8% of this breakdownItaly: 238 citing papers, 2.5% of this breakdownJapan: 225 citing papers, 2.4% of this breakdownAustralia: 202 citing papers, 2.2% of this breakdownIndia: 200 citing papers, 2.1% of this breakdownSwitzerland: 196 citing papers, 2.1% of this breakdown
0%26.3%Other 24%

Institutions

Fields

  • Biochemistry, Genetics and Molecular Biology51.3%
  • Medicine26%
  • Immunology and Microbiology9.9%
  • Chemistry5%
  • Computer Science2.9%
  • Neuroscience1.8%
  • Other3.1%

Topics

  • Ubiquitin and proteasome pathways11%
  • Peptidase Inhibition and Analysis3%
  • SARS-CoV-2 and COVID-19 Research2.9%
  • Protein Degradation and Inhibitors2.7%
  • Autophagy in Disease and Therapy2.6%
  • interferon and immune responses2.5%
  • Other75.3%

Coauthors

All papers

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  1. Proteome-wide identification of ubiquitin interactions using UbIA-MS

    Authors: Xiao-Fei Zhang, Arne H. Smits, Gabriëlle B. A. van Tilburg, Huib Ovaa, Wolfgang Huber, Michiel Vermeulen - Nature Protocols 2018 cited by 911

  2. Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

    Authors: Dong Hyuk Shin, Rukmini Mukherjee, Diana Grewe, Denisa Bojková, Kheewoong Baek, Anshu Bhattacharya, Laura Schulz, Marek Widera, Ahmad Reza Mehdipour, Georg Tascher, Paul P. Geurink, Alexander Wilhelm, Gerbrand J. van der Heden van Noort, Huib Ovaa, Stefan Müller, Klaus‐Peter Knobeloch, Krishnaraj Rajalingam, Brenda A. Schulman, Jindřich Činátl, Gerhard Hummer, Sandra Ciesek, Ivan Đikić - Nature 2020 cited by 1,247

  3. Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2

    Authors: Theresa Klemm, Gregor Ebert, Dale J. Calleja, Cody C. Allison, Lachlan W. Richardson, Jonathan P. Bernardini, Bernadine G.C. Lu, Nathan W. Kuchel, Christoph Grohmann, Y. Shibata, Zhong Yan Gan, James P. Cooney, Marcel Doerflinger, Amanda E. Au, T. Blackmore, Gerbrand J. van der Heden van Noort, Paul P. Geurink, Huib Ovaa, Janet Newman, Alan Riboldi‐Tunnicliffe, Peter E. Czabotar, Jeffrey P. Mitchell, Rebecca Feltham, Bernhard C. Lechtenberg, Kym N. Lowes, Grant Dewson, Marc Pellegrini, Guillaume Lessène, David Komander - The EMBO Journal 2020 cited by 494

  4. Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening

    Authors: Efrat Resnick, A.R. Bradley, Jinrui Gan, A. Douangamath, T. Krojer, Ritika Sethi, Paul P. Geurink, A. Aimon, Gabriel Amitai, Dom Bellini, James M. Bennett, M. Fairhead, Oleg Fedorov, Ronen Gabizon, Jin Gan, Jingxu Guo, A.N. Plotnikov, Nava Reznik, G.F. Ruda, L. Diaz Saez, Verena M. Straub, Tamás Szommer, Srikannathasan Velupillai, Daniel Zaidman, Yanling Zhang, Alun R. Coker, Christopher G. Dowson, Haim Barr, Chu Wang, K. Huber, Paul E. Brennan, Huib Ovaa, F. von Delft, Nir London - Journal of the American Chemical Society 2019 cited by 342

  5. OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis

    Authors: Tycho E.T. Mevissen, Manuela K. Hospenthal, Paul P. Geurink, P.R. Elliott, Masato Akutsu, N. Arnaudo, Reggy Ekkebus, Yogesh Kulathu, Tobias Wauer, Farid El Oualid, Stefan M.V. Freund, Huib Ovaa, David Komander - Cell 2013 cited by 642

  6. Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

    Authors: Rik van der Kant, Vanessa F. Langness, Cheryl Herrera, Daniel A. Williams, Lauren Fong, Yves Leestemaker, Evelyne Steenvoorden, Kevin D. Rynearson, Jos F. Brouwers, J. Bernd Helms, Huib Ovaa, Martin Giera, Steven L. Wagner, Anne G. Bang, Lawrence S.B. Goldstein - Cell stem cell 2019 cited by 373

  7. Ubiquitin ligation to F-box protein targets by SCF–RBR E3–E3 super-assembly

    Authors: Daniel Horn‐Ghetko, David T. Krist, J. Rajan Prabu, Kheewoong Baek, Monique P. C. Mulder, Maren Klügel, Daniel C. Scott, Huib Ovaa, Gary Kleiger, Brenda A. Schulman - Nature 2021 cited by 199

  8. USP8 promotes cancer progression and extracellular vesicle‐mediated CD8+ T cell exhaustion by deubiquitinating the TGF‐β receptor TβRII

    Authors: Feng Xie, Xiaoxue Zhou, Heyu Li, Peng Su, Sijia Liu, Ran Li, Jing Zou, Wei Xiang, Chen Pan, Zhengkui Zhang, Min Zheng, Zhuang Liu, Xuli Meng, Huib Ovaa, Peter ten Dijke, Fangfang Zhou, Long Zhang - The EMBO Journal 2022 cited by 89

  9. Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

    Authors: Baoxu Pang, Xiaohang Qiao, Lennert Janssen, Arno Velds, Tom A. Groothuis, Ron Kerkhoven, Marja Nieuwland, Huib Ovaa, Sven Rottenberg, Olaf van Tellingen, Jeroen J. W. M. Janssen, Peter C. Huijgens, Wilbert Zwart, Jacques Neefjes - Nature Communications 2013 cited by 431

  10. Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity

    Authors: Jorg van Loosdregt, Veerle Fleskens, Juan Fu, Arjan B. Brenkman, Cornelis P. J. Bekker, Cornelieke Pals, Jenny Meerding, Celia R. Berkers, Joseph Barbi, Andrea Gröne, Alice J.A.M. Sijts, Madelon M. Maurice, Eric Kalkhoven, Berent J. Prakken, Huib Ovaa, Fan Pan, Dietmar M. Zaiss, Paul J. Coffer - Immunity 2013 cited by 311

  11. Mechanism of USP7/HAUSP Activation by Its C-Terminal Ubiquitin-like Domain and Allosteric Regulation by GMP-Synthetase

    Authors: Alex C. Faesen, Annette M.G. Dirac, Anitha Shanmugham, Huib Ovaa, Anastassis Perrakis, Titia K. Sixma - Molecular Cell 2011 cited by 252

  12. On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases

    Authors: Reggy Ekkebus, Sander I. van Kasteren, Yogesh Kulathu, Arjen Scholten, Ilana Berlin, Paul P. Geurink, Annemieke de Jong, Soenita S. Goerdayal, Jacques Neefjes, Albert J. R. Heck, David Komander, Huib Ovaa - Journal of the American Chemical Society 2013 cited by 360

  13. An Interaction Landscape of Ubiquitin Signaling

    Authors: Xiaofei Zhang, Arne H. Smits, Gabriëlle B. A. van Tilburg, Pascal W.T.C. Jansen, Matthew Makowski, Huib Ovaa, Michiel Vermeulen - Molecular Cell 2017 cited by 163

  14. Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

    Authors: Daniel C. Scott, David Y. Rhee, David M. Duda, Ian R. Kelsall, Jennifer L. Olszewski, João A. Paulo, Annemieke de Jong, Huib Ovaa, Arno F. Alpi, J. Wade Harper, Brenda A. Schulman - Cell 2016 cited by 233

  15. Two Novel Ubiquitin-fold Modifier 1 (Ufm1)-specific Proteases, UfSP1 and UfSP2

    Authors: Sung Hwan Kang, Gi Ryang Kim, Minu Seong, Sung Hee Baek, Jae Hong Seol, Ok Sun Bang, Huib Ovaa, K. Tatsumi, Masaaki Komatsu, Keiji Tanaka, Chin Ha Chung - Journal of Biological Chemistry 2006 cited by 193

  16. BAP1/ASXL1 recruitment and activation for H2A deubiquitination

    Authors: Danny D. Sahtoe, Willem J. van Dijk, Reggy Ekkebus, Huib Ovaa, Titia K. Sixma - Nature Communications 2016 cited by 247

  17. Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis

    Authors: Sijia Liu, Román González‐Prieto, Mengdi Zhang, Paul P. Geurink, Raymond Kooij, Prasanna Vasudevan Iyengar, Maarten van Dinther, Erik Bos, Xiaobing Zhang, Sylvia E. Le Dévédec, Bob van de Water, Roman I. Koning, Hong‐Jian Zhu, Wilma E. Mesker, Alfred C.O. Vertegaal, Huib Ovaa, Long Zhang, John W.M. Martens, Peter ten Dijke - Clinical Cancer Research 2019 cited by 173

  18. Global non-covalent SUMO interaction networks reveal SUMO-dependent stabilization of the non-homologous end joining complex

    Authors: Román González‐Prieto, Karolin Eifler-Olivi, Laura A. Claessens, Edwin Willemstein, Zhenyu Xiao, Cami Talavera Ormeño, Huib Ovaa, Helle D. Ulrich, Alfred C.O. Vertegaal - Cell Reports 2021 cited by 75

  19. Structural basis of the specificity of USP18 toward ISG15

    Authors: Anja Basters, Paul P. Geurink, Annika Röcker, Katharina F. Witting, Roya Tadayon, Sandra Hess, Marta S. Semrau, Paola Storici, Huib Ovaa, Klaus‐Peter Knobeloch, G. Fritz - Nature Structural & Molecular Biology 2017 cited by 142

  20. Reactive glia show increased immunoproteasome activity in Alzheimer’s disease

    Authors: Marie Orre, Willem Kamphuis, Stephanie Dooves, Lieneke Kooijman, Elena T. Chan, Christopher J. Kirk, Vanessa D. Smith, Sanne Koot, Carlyn Mamber, Anne H. P. Jansen, Huib Ovaa, Elly M. Hol - Brain 2013 cited by 174

  21. Generation of peptide–MHC class I complexes through UV-mediated ligand exchange

    Authors: Boris Rodenko, Mireille Toebes, Sine Reker Hadrup, Wim J.E. van Esch, Annemieke M Molenaar, Ton N. Schumacher, Huib Ovaa - Nature Protocols 2006 cited by 327

  22. The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K

    Authors: Elma Mons, Ineke D.C. Jansen, Jure Loboda, Bjorn R. van Doodewaerd, J. P. G. Hermans, Martijn Verdoes, C. A. A. VAN BOECKEL, Peter A. van Veelen, Boris Turk, Dusan Turk, Huib Ovaa - Journal of the American Chemical Society 2019 cited by 115

  23. Chemistry-Based Functional Proteomics Reveals Novel Members of the Deubiquitinating Enzyme Family

    Authors: Anna Borodovsky, Huib Ovaa, Nagamalleswari Kolli, Tudeviin Gan‐Erdene, Keith D. Wilkinson, Hidde L. Ploegh, Benedikt M. Kessler - Chemistry & Biology 2002 cited by 596

  24. Chemical Synthesis of Ubiquitin, Ubiquitin‐Based Probes, and Diubiquitin

    Authors: Farid El Oualid, Remco Merkx, Reggy Ekkebus, Dharjath S. Hameed, Judith J. Smit, Annemieke de Jong, Henk Hilkmann, Titia K. Sixma, Huib Ovaa - Angewandte Chemie International Edition 2010 cited by 322