John D. Schuetz
Active 1984–2025
- 99
- Papers
- 21,493
- Citations
- 81
- h-index
- 95
- i10-index
Citations
Citation sources
Countries
Institutions
Fields
- Medicine60.5%
- Biochemistry, Genetics and Molecular Biology19.3%
- Pharmacology, Toxicology and Pharmaceutics14.2%
- Environmental Science1%
- Immunology and Microbiology0.9%
- Neuroscience0.9%
- Other3.2%
Topics
- Drug Transport and Resistance Mechanisms13%
- Pharmacogenetics and Drug Metabolism7.4%
- Pharmacological Effects and Toxicity Studies4.6%
- HIV/AIDS drug development and treatment2.1%
- Cancer Cells and Metastasis2%
- Drug-Induced Hepatotoxicity and Protection1.6%
- Other69.3%
Coauthors
- Erin G. Schuetz29
- Kazuto Yasuda12
- Yu Fukuda12
- Mary V. Relling11
- Masashi Adachi11
- Daxi Sun10
- J.A. Lynch9
- Philip S. Guzelian8
- Yao Wang8
- Stephen C. Strom7
- Hiroyuki Kusuhara6
- Lu-Bin Lan6
- Partha Krishnamurthy6
- William E. Evans6
- Yuichi Sugiyama6
- Brian P. Sorrentino5
- Clinton F. Stewart5
- Cynthia Brimer5
- Janardhan Sampath5
- Markos Leggas5
- Richard B. Kim5
- Robert C. Ford5
- Steven Wrighton5
- Frank J. Gonzalez4
All papers
- Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
Authors: Peter Kuehl, Jiong Zhang, Yvonne Lin, Jatinder K. Lamba, Mahfoud Assem, John D. Schuetz, Paul B. Watkins, Ann K. Daly, Steven Wrighton, Stephen D. Hall, P Maurel, Mary V. Relling, Cynthia Brimer, Kazuto Yasuda, Raman Venkataramanan, Stephen C. Strom, Kenneth E. Thummel, Mark S. Boguski, Erin G. Schuetz - Nature Genetics 2001 cited by 2,161
- The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
Authors: Sheng Zhou, John D. Schuetz, Kevin D. Bunting, Anne-Marie Colapietro, Janardhan Sampath, John J. Morris, Irina V. Lagutina, Gerard C. Grosveld, Mitsujiro Osawa, Hiromitsu Nakauchi, Brian P. Sorrentino - Nature Medicine 2001 cited by 2,276
- Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction
Authors: Xi Wang, Madhavi Bathina, J.A. Lynch, Brian Koss, Christopher Calabrese, Sharon Frase, John D. Schuetz, Jerold E. Rehg, Joseph T. Opferman - Genes & Development 2013 cited by 272
- The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma
Authors: Min Pan, William C. Wright, Richard H. Chapple, Asif Zubair, Manbir Sandhu, Jake E. Batchelder, Brandt C. Huddle, Jonathan Low, Kaley Blankenship, Yingzhe Wang, Brittney Gordon, Payton Archer, Samuel W. Brady, Sivaraman Natarajan, Matthew J. Posgai, John D. Schuetz, Darcie J. Miller, Ravi Kalathur, Siquan Chen, Jon P. Connelly, M. Madan Babu, Michael A. Dyer, Shondra M. Pruett‐Miller, Burgess B. Freeman, Taosheng Chen, Lucy A. Godley, Scott C. Blanchard, Elizabeth Stewart, John Easton, Paul Geeleher - Nature Communications 2021 cited by 93
- Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration
Authors: Rhonda M. Perciavalle, Daniel P. Stewart, Brian Koss, J.A. Lynch, Sandra Milasta, Madhavi Bathina, Jamshid Temirov, Megan M. Cleland, S. William Pelletier, John D. Schuetz, Richard J. Youle, Douglas R. Green, Joseph T. Opferman - Nature Cell Biology 2012 cited by 400
- Identification of a mammalian mitochondrial porphyrin transporter
Authors: Partha Krishnamurthy, Guoqing Du, Yu Fukuda, Daxi Sun, Janardhan Sampath, Kelly E. Mercer, Junfeng Wang, Beatriz Sosa‐Pineda, K. Gopal Murti, John D. Schuetz - Nature 2006 cited by 355
- AI-Enhanced Adaptive Virtual Screening Platform Enabling Exploration of 69 Billion Molecules Discovers Structurally Validated FSP1 Inhibitors
Authors: Christoph Gorgulla, AkshatKumar Nigam, AkshatKumar Nigam, Ming Tang, Matt Koop, Matt Koop, Callum Robert Nicoll, Yao Wang, Abhilash Jayaraj, Suleyman Selim Cinaroglu, Ricarda Törner, Yehor Malets, Minko Gehev, Christopher Secker, Mohammad Haddadnia, Yehor S. Malets, Alexander Hasson, Yong Li, Hyuk-Soo Seo, Sirano Dhe-Paganon, M Li, Kumar Abhishek, Roni Levin‐Konigsberg, Minkai Li, Abhishek Kumar, Roni Levin-Konigsberg, Eun-Bee Choi, Geoffrey I. Shapiro, Huel Cox, Luke Sebastian, Aditya Kumar, Minko Gehev, Pierre-Yves Aquilanti, Henry A. Gabb, Amr Alhossary, Gerhard Wagner, Alán Aspuru‐Guzik, Yurii S. Moroz, Gerhard Wagner, Konstantin Fackeldey, Yurii S. Moroz, Haribabu Arthanari, Konstantin Fackeldey, John D. Schuetz, Andrea Mattevi, Haribabu Arthanari, Christoph Gorgulla - 2023 cited by 26
- The Arachidonic Acid Metabolome Serves as a Conserved Regulator of Cholesterol Metabolism
Authors: Egon Demetz, Andrea Schroll, Kristina Auer, Christiane Heim, Josef R. Patsch, Kathrin Eller, Markus Theurl, Igor Theurl, Milan Theurl, Markus Seifert, Daniela Lener, Ursula Stanzl, David Haschka, Malte Aßhoff, Stefanie Dichtl, Manfred Nairz, E. Huber, Martin Stadlinger, Alexander R. Moschen, Xiaorong Li, Petra Pallweber, Hubert Scharnagl, Tatjana Stojaković, Winfried März, Marcus E. Kleber, K. Garlaschelli, Patrizia Uboldi, Alberico L. Catapano, Frans Stellaard, Mats Rudling, Keiji Kuba, Yumiko Imai, Makoto Arita, John D. Schuetz, Peter P. Pramstaller, Uwe J.F. Tietge, Michael Trauner, Giuseppe Danilo Norata, Thierry Claudel, Andrew A. Hicks, Günter Weiß, Ivan Tancevski - Cell Metabolism 2014 cited by 117
- Linker Domains: Why ABC Transporters ‘Live in Fragments no Longer’
Authors: Robert C. Ford, Dominic Marshall-Sabey, John D. Schuetz - Trends in Biochemical Sciences 2019 cited by 42
- Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice
Authors: Martin Wagner, Peter Fickert, Gernot Zollner, Andrea Fuchsbichler, Dagmar Silbert, Oleksiy Tsybrovskyy, Kurt Zatloukal, Grace L. Guo, John D. Schuetz, Frank J. Gonzalez, Hanns–Ulrich Marschall, Helmut Denk, Michael Trauner - Gastroenterology 2003 cited by 261
- Mutant p53 Cooperates with ETS and Selectively Up-regulates Human MDR1 Not MRP1
Authors: Janardhan Sampath, Daxi Sun, Vincent J. Kidd, José Grenet, Amisha Gandhi, Linda H. Shapiro, Qingjian Wang, Gerard P. Zambetti, John D. Schuetz - Journal of Biological Chemistry 2001 cited by 244
- Obstacles to Brain Tumor Therapy: Key ABC Transporters
Authors: Juwina Wijaya, Yu Fukuda, John D. Schuetz - International Journal of Molecular Sciences 2017 cited by 104
- The Stem Cell Marker Bcrp/ABCG2 Enhances Hypoxic Cell Survival through Interactions with Heme
Authors: Partha Krishnamurthy, Douglas D. Ross, Takeo Nakanishi, Kim Bailey-Dell, Sheng Zhou, Kelly E. Mercer, Balázs Sarkadi, Brian P. Sorrentino, John D. Schuetz - Journal of Biological Chemistry 2004 cited by 653
- Disrupted Bile Acid Homeostasis Reveals an Unexpected Interaction among Nuclear Hormone Receptors, Transporters, and Cytochrome P450
Authors: Erin G. Schuetz, Stephen C. Strom, Kazuto Yasuda, Valérie Lecureur, Mahfoud Assem, Cynthia Brimer, Jatinder K. Lamba, Richard B. Kim, Vinod Ramachandran, Bernard J. Komoroski, Raman Venkataramanan, Hongbo Cai, Christopher J. Sinal, Frank J. Gonzalez, John D. Schuetz - Journal of Biological Chemistry 2001 cited by 391
- Imatinib Mesylate Is a Potent Inhibitor of the ABCG2 (BCRP) Transporter and Reverses Resistance to Topotecan and SN-38 in Vitro
Authors: Peter J. Houghton, Glen S. Germain, Franklin C. Harwood, John D. Schuetz, Clinton F. Stewart, Elisabeth Buchdunger, Peter Traxler - Cancer Research 2004 cited by 322
- The role of transporters in cellular heme and porphyrin homeostasis
Authors: Partha Krishnamurthy, Tao Xie, John D. Schuetz - Pharmacology & Therapeutics 2007 cited by 267
- Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport
Authors: Da‐Qing Jin, Terri T. Ni, Jianjian Sun, Haiyan Wan, Jeffrey D. Amack, Guangju Yu, Jonathan T. Fleming, Chin Chiang, Wenyan Li, Anna Papierniak, Satish Cheepala, Gwenaëlle Conseil, Susan P.C. Cole, Bin Zhou, Iain A. Drummond, John D. Schuetz, Jarema Malicki, Tao P. Zhong - Nature Cell Biology 2014 cited by 105
- Abcb11 Deficiency Induces Cholestasis Coupled to Impaired β-Fatty Acid Oxidation in Mice
Authors: Yuanyuan Zhang, Fei Li, Andrew D. Patterson, Yao Wang, Kristopher W. Krausz, Geoffrey Neale, Sarah Thomas, Deepa Nachagari, Peter Vogel, Mary Vore, Frank J. Gonzalez, John D. Schuetz - Journal of Biological Chemistry 2012 cited by 86
- Transcriptional Control of Intestinal Cytochrome P-4503A by 1α,25-Dihydroxy Vitamin D3
Authors: Kenneth E. Thummel, Cynthia Brimer, Kazuto Yasuda, Jaideep V. Thottassery, Tauri Senn, Yvonne Lin, Hitoshi Ishizuka, Evan D. Kharasch, John D. Schuetz, Erin G. Schuetz - Molecular Pharmacology 2001 cited by 324
- Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4)
Authors: Noam Zelcer, Glen Reid, Peter R. Wielinga, Annemieke Kuil, Ingrid van der Heijden, John D. Schuetz, Piet Borst - Biochemical Journal 2003 cited by 311
- ABC transporters and their role in nucleoside and nucleotide drug resistance
Authors: Yu Fukuda, John D. Schuetz - Biochemical Pharmacology 2012 cited by 123
- Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters
Authors: Samit Ganguly, David Finkelstein, Timothy I. Shaw, Ryan D. Michalek, Kimberly M. Zorn, Sean Ekins, Kazuto Yasuda, Yu Fukuda, John D. Schuetz, Kamalika Mukherjee, Erin G. Schuetz - PLoS ONE 2021 cited by 20
- MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs
Authors: John D. Schuetz, Michele Connelly, Daxi Sun, Sheela G. Paibir, Patricia M. Flynn, R V Srinivas, Alok Kumar, Arnold Fridland - Nature Medicine 1999 cited by 579
- High-Affinity Interaction of Tyrosine Kinase Inhibitors with the ABCG2 Multidrug Transporter
Authors: Csilla Özvegy‐Laczka, Tamás Hegedűs, György Várady, Olga Ujhelly, John D. Schuetz, András Váradi, Gÿorgý Kéri, László Őrfi, Katalin Német, Balázs Sarkadi - Molecular Pharmacology 2004 cited by 340
