Mark P. Jedrychowski
Active 2004–2025
- 81
- Papers
- 33,729
- Citations
- 63
- h-index
- 81
- i10-index
Citations
Citation sources
Countries
Institutions
- Harvard University2.3%
- Dana-Farber Cancer Institute0.7%
- Inserm0.5%
- Howard Hughes Medical Institute0.5%
- Broad Institute0.5%
- Massachusetts General Hospital0.5%
- Other95%
Fields
- Medicine42.8%
- Biochemistry, Genetics and Molecular Biology34.4%
- Neuroscience11%
- Immunology and Microbiology5.1%
- Chemistry4.3%
- Agricultural and Biological Sciences0.6%
- Other1.8%
Topics
- Adipose Tissue and Metabolism8.1%
- Neuroinflammation and Neurodegeneration Mechanisms4%
- Sirtuins and Resveratrol in Medicine3.3%
- Adipokines, Inflammation, and Metabolic Diseases2.9%
- Autophagy in Disease and Therapy2.6%
- Mitochondrial Function and Pathology2.6%
- Other76.5%
Coauthors
- Steven P. Gygi50
- Bruce M. Spiegelman26
- Edward T. Chouchani16
- Lawrence Kazak11
- Pere Puigserver11
- John Szpyt10
- Evanna L. Mills8
- Haopeng Xiao8
- Gina Z. Lu7
- João A. Paulo7
- Brian K. Erickson6
- Christiane D. Wrann6
- Christopher F. Bennett6
- Dina Laznik-Bogoslavski6
- Edward L. Huttlin6
- Jonathan Z. Long6
- Ryan Garrity6
- Shingo Kajimura6
- Steve P. Gygi6
- Alexander S. Banks5
- Anita Reddy5
- Devin K. Schweppe5
- Eduardo Balsa5
- Tsuneya Ikezu5
All papers
- Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Authors: Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zasłona, Mark P. Jedrychowski, Ana S.H. Costa, Maureen Higgins, Emily Hams, John Szpyt, Marah C. Runtsch, Martin King, Joanna F. McGouran, Román Fischer, Benedikt M. Kessler, Anne F. McGettrick, Mark Hughes, Richard G. Carroll, Lee M. Booty, Elena V. Knatko, Paul J. Meakin, Michael L.J. Ashford, Louise K. Modis, Gino Brunori, Daniel C. Sévin, Padraic G. Fallon, Stuart T. Caldwell, Edmund R.S. Kunji, Edward T. Chouchani, Christian Frezza, Albena T. Dinkova‐Kostova, Richard C. Hartley, Michael P. Murphy, Luke O'neill - Nature 2018 cited by 1,905
- A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Authors: Pontus Boström, Jun Wu, Mark P. Jedrychowski, Anisha Korde, Li Ye, James C. Lo, Kyle A. Rasbach, Elisabeth A. Boström, Jang Hyun Choi, Jonathan Z. Long, Shingo Kajimura, Maria Cristina Zingaretti, Birgitte F. Vind, Hua Tu, Saverio Cinti, Kurt Højlund, Steven P. Gygi, Bruce M. Spiegelman - Nature 2012 cited by 4,772
- Identification of a unique TGF-β–dependent molecular and functional signature in microglia
Authors: Oleg Butovsky, Mark P. Jedrychowski, Craig S. Moore, Ron Cialic, Amanda J. Lanser, Galina Gabriely, Thomas Koeglsperger, Ben Dake, Pauline Wu, Camille Doykan, Zain Fanek, Liping Liu, Zhuoxun Chen, Jeffrey D. Rothstein, Richard M. Ransohoff, Steven P. Gygi, Jack P. Antel, Howard L. Weiner - Nature Neuroscience 2013 cited by 2,642
- Quantitative Proteomics of the Cancer Cell Line Encyclopedia
Authors: David P. Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald, Marian Kalocsay, Judit Jané‐Valbuena, Ellen Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji, Dale Porter, Tomáš Rejtar, Yan Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi A. Garraway, William R. Sellers, Steven P. Gygi - Cell 2020 cited by 1,061
- Plasticity in binding confers selectivity in ligand-induced protein degradation
Authors: Radosław P. Nowak, Stephen L. DeAngelo, Dennis L. Buckley, Zhixiang He, Katherine A. Donovan, Jian An, Nozhat Safaee, Mark P. Jedrychowski, Charles M. Ponthier, Mette Ishoey, Tinghu Zhang, Joseph D. Mancias, Nathanael S. Gray, James E. Bradner, Eric S. Fischer - Nature Chemical Biology 2018 cited by 631
- A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression
Authors: Edward L. Huttlin, Mark P. Jedrychowski, Joshua E. Elias, Tapasree Goswami, Ramin Rad, Sean A. Beausoleil, Judit Villén, Wilhelm Haas, Mathew E. Sowa, Steven P. Gygi - Cell 2010 cited by 1,867
- MultiNotch MS3 Enables Accurate, Sensitive, and Multiplexed Detection of Differential Expression across Cancer Cell Line Proteomes
Authors: Graeme C. McAlister, David P. Nusinow, Mark P. Jedrychowski, Martin Wühr, Edward L. Huttlin, Brian K. Erickson, Ramin Rad, Wilhelm Haas, Steven P. Gygi - Analytical Chemistry 2014 cited by 1,380
- Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
Authors: Hyeonwoo Kim, Christiane D. Wrann, Mark P. Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman - Cell 2018 cited by 632
- Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
Authors: Anne Brunet, Lora B. Sweeney, James Fitzhugh Sturgill, Katrin F. Chua, Paul L. Greer, Yingxi Lin, Hien Tran, Sarah E. Ross, Raúl Mostoslavsky, Haim Cohen, Linda Hu, Hwei-Ling Cheng, Mark P. Jedrychowski, Steven P. Gygi, David Sinclair, Frederick W. Alt, Michael E. Greenberg - Science 2004 cited by 3,260
- Lactate regulates cell cycle by remodelling the anaphase promoting complex
Authors: Weihai Liu, Yun Wang, Luiz H. M. Bozi, Patrick D. Fischer, Mark P. Jedrychowski, Haopeng Xiao, Tao Wu, Narek Darabedian, Xiadi He, Evanna L. Mills, Nils Burger, Sang-Hee Shin, Anita Reddy, Hans‐Georg Sprenger, Nhien Tran, Sally Winther, Stephen M. Hinshaw, Jingnan Shen, Hyuk‐Soo Seo, Kijun Song, Andrew Z. Xu, Luke Sebastian, Jean J. Zhao, Sirano Dhe‐Paganon, Jianwei Che, Steven P. Gygi, Haribabu Arthanari, Edward T. Chouchani - Nature 2023 cited by 206
- Exercise hormone irisin is a critical regulator of cognitive function
Authors: Mohammad Rashedul Islam, Sophia Valaris, Michael Young, Erin B. Haley, Renhao Luo, Sabrina F. Bond, Sofia Mazuera, Robert R. Kitchen, Barbara J. Caldarone, Luis E.B. Bettio, Brian R. Christie, Angela B. Schmider, Roy J. Soberman, B Antoine, Mark P. Jedrychowski, Hyeonwoo Kim, Hua Tu, Eunhee Kim, Se Hoon Choi, Rudolph E. Tanzi, Bruce M. Spiegelman, Christiane D. Wrann - Nature Metabolism 2021 cited by 389
- A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat
Authors: Lawrence Kazak, Edward T. Chouchani, Mark P. Jedrychowski, Brian K. Erickson, Kosaku Shinoda, Paul Cohen, Ramalingam Vetrivelan, Gina Z. Lu, Dina Laznik-Bogoslavski, Sebastian C. Hasenfuss, Shingo Kajimura, Steve P. Gygi, Bruce M. Spiegelman - Cell 2015 cited by 789
- A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging
Authors: Haopeng Xiao, Mark P. Jedrychowski, Devin K. Schweppe, Edward L. Huttlin, Qing Yu, David E. Heppner, Jiaming Li, Jiani Long, Evanna L. Mills, John Szpyt, Zhixiang He, Guangyan Du, Ryan Garrity, Anita Reddy, Laura Pontano Vaites, João A. Paulo, Tinghu Zhang, Nathanael S. Gray, Steven P. Gygi, Edward T. Chouchani - Cell 2020 cited by 432
- Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis
Authors: Rajesh R. Rao, Jonathan Z. Long, James P. White, Katrin J. Svensson, Jesse Lou, Isha A. Lokurkar, Mark P. Jedrychowski, Jorge L. Ruas, Christiane D. Wrann, James C. Lo, Donny M. Camera, Jenn Lachey, Steven P. Gygi, Jasbir Seehra, John A. Hawley, Bruce M. Spiegelman - Cell 2014 cited by 964
- Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis
Authors: Alban Ordureau, Shireen A. Sarraf, David M. Duda, Jin‐Mi Heo, Mark P. Jedrychowski, Vladislav O. Sviderskiy, Jennifer L. Olszewski, James T. Koerber, Tiao Xie, Sean A. Beausoleil, James A. Wells, Steven P. Gygi, Brenda A. Schulman, J. Wade Harper - Molecular Cell 2014 cited by 715
- Accumulation of succinate controls activation of adipose tissue thermogenesis
Authors: Evanna L. Mills, Kerry A. Pierce, Mark P. Jedrychowski, Ryan Garrity, Sally Winther, Sara Vidoni, Takeshi Yoneshiro, Jessica B. Spinelli, Gina Z. Lu, Lawrence Kazak, Alexander S. Banks, Marcia C. Haigis, Shingo Kajimura, Michael P. Murphy, Steven P. Gygi, Clary B. Clish, Edward T. Chouchani - Nature 2018 cited by 547
- ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2α Axis
Authors: Eduardo Balsa, Meghan S. Soustek, Ajith J. Thomas, Sara Cogliati, Carolina García‐Poyatos, Elena Martín‐García, Mark P. Jedrychowski, Steve P. Gygi, José Antonio Enrı́quez, Pere Puigserver - Molecular Cell 2019 cited by 327
- Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry
Authors: Mark P. Jedrychowski, Christiane D. Wrann, João A. Paulo, Kaitlyn K. Gerber, John Szpyt, Matthew M. Robinson, K. Sreekumaran Nair, Steven P. Gygi, Bruce M. Spiegelman - Cell Metabolism 2015 cited by 550
- Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization
Authors: Wen Yang, Koji Nagasawa, Christian Münch, Yingjie Xu, F. Kyle Satterstrom, Seung–Min Jeong, Sebastian Hayes, Mark P. Jedrychowski, Foram Vyas, Elma Zaganjor, Virgínia Guarani, Alison E. Ringel, Steven P. Gygi, J. Wade Harper, Marcia C. Haigis - Cell 2016 cited by 347
- Human neural cell type‐specific extracellular vesicle proteome defines disease‐related molecules associated with activated astrocytes in Alzheimer's disease brain
Authors: Yang You, Satoshi Muraoka, Mark P. Jedrychowski, Jianqiao Hu, Amanda McQuade, Tracy L. Young‐Pearse, Roshanak Aslebagh, Scott A. Shaffer, Steven P. Gygi, Mathew Blurton‐Jones, Wayne W. Poon, Tsuneya Ikezu - Journal of Extracellular Vesicles 2022 cited by 155
- Creatine kinase B controls futile creatine cycling in thermogenic fat
Authors: Janane F. Rahbani, Anna Roesler, Mohammed F. Hussain, Bożena Samborska, Christien B. Dykstra, Linus Tsai, Mark P. Jedrychowski, Laurent Vergnes, Karen Reue, Bruce M. Spiegelman, Lawrence Kazak - Nature 2021 cited by 218
- Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease
Authors: Zhuoran Yin, Shawn Herron, Sebastian Silveira, Kilian Kleemann, Christian Gauthier, Dania Mallah, Yiran Cheng, Milica A. Margeta, Kristen Pitts, Jen‐Li Barry, Ayshwarya Subramanian, H. H. Shorey, Wesley Nogueira Brandão, Ana Durao, Jean-Christophe Delpech, Charlotte Madore, Mark P. Jedrychowski, Amrendra K. Ajay, Gopal Murugaiyan, Samuel Hersh, Seiko Ikezu, Tsuneya Ikezu, Oleg Butovsky - Nature Neuroscience 2023 cited by 111
- UCP1 governs liver extracellular succinate and inflammatory pathogenesis
Authors: Evanna L. Mills, Cathal Harmon, Mark P. Jedrychowski, Haopeng Xiao, Ryan Garrity, Nhien Tran, Gary A. Bradshaw, Accalia Fu, John Szpyt, Anita Reddy, Hannah Prendeville, Nika N. Danial, Steven P. Gygi, Lydia Lynch, Edward T. Chouchani - Nature Metabolism 2021 cited by 176
- Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling
Authors: Eunhee Kim, Hyeonwoo Kim, Mark P. Jedrychowski, Grisilda Bakiasi, Joseph Park, Jane M. Kruskop, Younjung Choi, Sang Su Kwak, Luisa Quinti, Doo Yeon Kim, Christiane D. Wrann, Bruce M. Spiegelman, Rudolph E. Tanzi, Se Hoon Choi - Neuron 2023 cited by 111
