Phillip T. Hawkins
Active 1983–2025
- 92
- Papers
- 19,912
- Citations
- 76
- h-index
- 89
- i10-index
Citations
Citation sources
Countries
Institutions
Fields
- Biochemistry, Genetics and Molecular Biology56%
- Medicine23.9%
- Immunology and Microbiology12.7%
- Neuroscience3.2%
- Agricultural and Biological Sciences1.8%
- Chemistry0.6%
- Other1.8%
Topics
- Protein Kinase Regulation and GTPase Signaling8%
- PI3K/AKT/mTOR signaling in cancer7%
- Cellular transport and secretion4.5%
- Cell Adhesion Molecules Research2.2%
- Cellular Mechanics and Interactions2%
- Immune Cell Function and Interaction1.8%
- Other74.5%
Coauthors
- Len Stephens75
- Karen E. Anderson31
- Jonathan Clark12
- Keith Davidson12
- Trevor Jackson11
- Chris D. Ellson9
- Sabine Suire9
- Heidi C. E. Welch8
- John Coadwell8
- A. Eguinoa7
- C. Peter Downes7
- Gail Ferguson7
- David Barneda6
- Frank T. Cooke6
- Hediye Erdjument‐Bromage6
- Paul Tempst6
- Roger Williams6
- Andrew B. Holmes5
- Anna Kielkowska5
- David Oxley5
- Izabella Niewczas5
- Simon Andrews5
- Sonja Krugmann5
- Tamara Chessa5
All papers
- A small-molecule PI3Kα activator for cardioprotection and neuroregeneration
Authors: Grace Q. Gong, Benoît Bilanges, Ben Allsop, Glenn R. Masson, Victoria H. Roberton, Trevor Askwith, Sally Oxenford, Ralitsa R. Madsen, Sarah E. Conduit, Dom Bellini, Martina Fitzek, M. Collier, Osman Najam, Zhenhe He, Ben Wahab, Stephen H. McLaughlin, A. W. Edith Chan, Isabella Feierberg, Andrew Madin, Daniele Morelli, Amandeep Bhamra, Vanesa Vinciauskaite, Karen E. Anderson, Silvia Šurinová, Nikos Pinotsis, Elena Lopez-Guadamillas, Matthew Wilcox, Alice Hooper, Chandni Patel, Maria A. Whitehead, Tom D. Bunney, Len Stephens, Phillip T. Hawkins, Matilda Katan, Derek M. Yellon, Sean M. Davidson, David M. Smith, James B. Phillips, Richard Angell, Roger Williams, Bart Vanhaesebroeck - Nature 2023 cited by 151
- PI3K signalling: the path to discovery and understanding
Authors: Bart Vanhaesebroeck, Len Stephens, Phillip T. Hawkins - Nature Reviews Molecular Cell Biology 2012 cited by 988
- PI3K signalling in inflammation
Authors: Phillip T. Hawkins, Len Stephens - Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2014 cited by 542
- Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage
Authors: Ivan L. Ângulo, Oscar Vadas, Fabien Garçon, Edward Banham-Hall, Vincent Plagnol, Timothy Ronan Leahy, Helen Baxendale, Tanya Coulter, James Curtis, Changxin Wu, Katherine G. Blake-Palmer, Olga Perišić, Deborah J. Smyth, Mailis Maes, Christine Fiddler, Jatinder K. Juss, Deirdre Cilliers, Gašper Markelj, Anita Chandra, George E. Farmer, Anna Kielkowska, Jonathan Clark, Sven Kracker, Marianne Debré, Capucine Pïcard, Isabelle Pellier, Nada Jabado, James Morris, Gabriela Barcenas‐Morales, Alain Fischer, Len Stephens, Phillip T. Hawkins, Jeffrey C. Barrett, Mario Abinun, Menna R. Clatworthy, Anne Durandy, Rainer Döffinger, Edwin R. Chilvers, Andrew J. Cant, Dinakantha Kumararatne, Klaus Okkenhaug, Roger Williams, Alison M. Condliffe, Sergey Nejentsev - Science 2013 cited by 631
- Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy
Authors: Dávid Győri, Ee Lyn Lim, Francis M. Grant, Dominik Spensberger, Rahul Roychoudhuri, Stephen J. Shuttleworth, Klaus Okkenhaug, Len Stephens, Phillip T. Hawkins - JCI Insight 2018 cited by 143
- SCFAs Induce Mouse Neutrophil Chemotaxis through the GPR43 Receptor
Authors: Marco Aurélio Ramirez Vinolo, Gail Ferguson, Suhasini Kulkarni, George Damoulakis, Karen E. Anderson, Mohammad Bohlooly‐Y, Len Stephens, Phillip T. Hawkins, Rui Curi - PLoS ONE 2011 cited by 287
- The cytotoxic T cell proteome and its shaping by the kinase mTOR
Authors: Jens Hukelmann, Karen E. Anderson, Linda V. Sinclair, Katarzyna M. Grzes, Alejandro Brenes Murillo, Phillip T. Hawkins, Len Stephens, Angus I. Lamond, Doreen A. Cantrell - Nature Immunology 2015 cited by 258
- The synthetic TRPML1 agonist ML-SA1 rescues Alzheimer-related alterations of the endosomal-autophagic-lysosomal system
Authors: Aleksandra Somogyi, Emily D. Kirkham, Emyr Lloyd‐Evans, Jincy Winston, Nicholas D. Allen, John J. Mackrill, Karen E. Anderson, Phillip T. Hawkins, Sian E. Gardiner, Helen Waller‐Evans, Rebecca Sims, Barry Boland, Cora O’Neill - Journal of Cell Science 2023 cited by 51
- Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B
Authors: David Stokoe, Leonard R. Stephens, Terry Copeland, Piers R. J. Gaffney, Colin B. Reese, Gavin F. Painter, Andrew B. Holmes, Frank McCormick, Phillip T. Hawkins - Science 1997 cited by 1,213
- Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ
Authors: Michael E. Pacold, Sabine Suire, Olga Perišić, Samuel Lara‐González, Colin Davis, Edward H. Walker, Phillip T. Hawkins, Len Stephens, John F. Eccleston, Roger Williams - Cell 2000 cited by 631
- Functional drug screening reveals anticonvulsants as enhancers of mTOR‐independent autophagic killing of Mycobacterium tuberculosis through inositol depletion
Authors: Mark Schiebler, Karen Brown, Krisztina Hegyi, Sandra M. Newton, Maurizio Renna, Lucy Hepburn, Catherine Klapholz, Sarah Coulter, Andrés Obregón‐Henao, Marcela Henao Tamayo, Randall J. Basaraba, Beate Kampmann, Katherine M. Henry, Joseph Burgon, Stephen A. Renshaw, Angeleen Fleming, Robert R. Kay, Karen E. Anderson, Phillip T. Hawkins, Diane Ordway, David C. Rubinsztein, R. Andrés Floto - EMBO Molecular Medicine 2014 cited by 156
- Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B
Authors: Len Stephens, Karen E. Anderson, David Stokoe, Hediye Erdjument‐Bromage, Gavin F. Painter, Andrew B. Holmes, Piers R. J. Gaffney, Colin B. Reese, Frank McCormick, Paul Tempst, John Coadwell, Phillip T. Hawkins - Science 1998 cited by 1,063
- Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism
Authors: Xuxiao Zhang, Oscar Vadas, Olga Perišić, Karen E. Anderson, Jonathan Clark, Phillip T. Hawkins, Len Stephens, Roger Williams - Molecular Cell 2011 cited by 208
- Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8 + T Cells
Authors: Sarah H. Ross, Christina Rollings, Karen E. Anderson, Phillip T. Hawkins, Len Stephens, Doreen A. Cantrell - Immunity 2016 cited by 92
- P-Rex1, a PtdIns(3,4,5)P3- and Gβγ-Regulated Guanine-Nucleotide Exchange Factor for Rac
Authors: Heidi C. E. Welch, W. John Coadwell, Christian D. Ellson, Gail Ferguson, Simon Andrews, Hediye Erdjument‐Bromage, Paul Tempst, Phillip T. Hawkins, Len Stephens - Cell 2002 cited by 486
- Signalling through Class I PI3Ks in mammalian cells
Authors: Phillip T. Hawkins, Karen E. Anderson, Keith Davidson, Len Stephens - Biochemical Society Transactions 2006 cited by 533
- Two distinct functions for PI3-kinases in macropinocytosis
Authors: Oliver Hoeller, Parvin Bolourani, Jonathan Clark, Len Stephens, Phillip T. Hawkins, Orion D. Weiner, Gerald Weeks, Robert R. Kay - Journal of Cell Science 2013 cited by 111
- Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase
Authors: Glenn F. W. Walpole, Jonathan Pacheco, Neha Chauhan, Jonathan Clark, Karen E. Anderson, Y.M. Abbas, Danielle Brabant-Kirwan, Fernando Montaño-Rendón, Zetao Liu, Hongxian Zhu, John H. Brumell, Alexander Deiters, Len Stephens, Phillip T. Hawkins, Gerald Hammond, Sergio Grinstein, Gregory D. Fairn - Nature Cell Biology 2022 cited by 42
- Neutrophils from p40phox−/− mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing
Authors: Chris D. Ellson, Keith Davidson, Gail Ferguson, Rodney P. O’Connor, Len Stephens, Phillip T. Hawkins - The Journal of Experimental Medicine 2006 cited by 190
- PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K
Authors: Mouhannad Malek, Anna Kielkowska, Tamara Chessa, Karen E. Anderson, David Barneda, Pınar Pir, Hiroki Nakanishi, Satoshi Eguchi, Atsushi Koizumi, Junko Sasaki, Véronique Juvin, Vladimir Yu Kiselev, Izabella Niewczas, Alexander Gray, Alexandre Valayer, Dominik Spensberger, Marine Imbert, Sérgio Luís Felisbino, Tomonori Habuchi, Sören Beinke, Sabina Cosulich, Nicolas Le Novère, Takehiko Sasaki, Jonathan Clark, Phillip T. Hawkins, Len Stephens - Molecular Cell 2017 cited by 184
- Age-related decline in the resistance of mice to bacterial infection and in LPS/TLR4 pathway-dependent neutrophil responses
Authors: Kirsti Hornigold, Julia Y. Chu, Stephen A. Chetwynd, Polly A. Machin, Laraine Crossland, Chiara Pantarelli, Karen E. Anderson, Phillip T. Hawkins, Anne Segonds-Pichon, David Oxley, Heidi C. E. Welch - Frontiers in Immunology 2022 cited by 32
- The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101
Authors: Len Stephens, A. Eguinoa, Hediye Erdjument‐Bromage, Michelle Lui, Frank T. Cooke, John Coadwell, Alan Smrcka, Marcus Thelen, Karen A. Cadwallader, Paul Tempst, Phillip T. Hawkins - Cell 1997 cited by 561
- Phosphoinositide 3‐kinase‐dependent activation of Rac
Authors: Heidi C. E. Welch, W. John Coadwell, Len Stephens, Phillip T. Hawkins - FEBS Letters 2003 cited by 322
- Platelet-derived growth factor stimulates synthesis of Ptdlns(3,4,5)P3 by activating a Ptdlns(4,5)P2 3-OH kinase
Authors: Phillip T. Hawkins, Trevor Jackson, Len Stephens - Nature 1992 cited by 244
