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Timothy M. Willson

Active 1988–2025

Also published as
Timothy M Willson
171
Papers
65,316
Citations
110
h-index
163
i10-index

Citations

Citations per year for Timothy M. Willson1987: 2 citations1988: 1 citations1989: 2 citations1994: 4 citations1995: 14 citations1996: 69 citations1997: 148 citations1998: 292 citations1999: 475 citations2000: 780 citations2001: 894 citations2002: 1,314 citations2003: 1,398 citations2004: 1,246 citations2005: 1,173 citations2006: 1,218 citations2007: 1,040 citations2008: 999 citations2009: 808 citations2010: 852 citations2011: 638 citations2012: 676 citations2013: 640 citations2014: 541 citations2015: 451 citations2016: 433 citations2017: 532 citations2018: 504 citations2019: 1,361 citations2020: 1,366 citations2021: 1,292 citations2022: 959 citations2023: 741 citations2024: 961 citations2025: 533 citations2026: 20 citations1990–1993: no citations, so these years are not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 6,884 citing papers, 33.6% of this breakdownChina: 1,751 citing papers, 8.6% of this breakdownUnited Kingdom: 1,321 citing papers, 6.5% of this breakdownGermany: 1,047 citing papers, 5.1% of this breakdownFrance: 943 citing papers, 4.6% of this breakdownJapan: 893 citing papers, 4.4% of this breakdownItaly: 684 citing papers, 3.3% of this breakdownCanada: 665 citing papers, 3.2% of this breakdownNetherlands: 487 citing papers, 2.4% of this breakdownSweden: 481 citing papers, 2.3% of this breakdownSwitzerland: 472 citing papers, 2.3% of this breakdownAustralia: 438 citing papers, 2.1% of this breakdown
0%33.6%Other 21.6%

Institutions

Fields

  • Medicine39.7%
  • Biochemistry, Genetics and Molecular Biology38.7%
  • Pharmacology, Toxicology and Pharmaceutics4.4%
  • Neuroscience4.2%
  • Computer Science3.5%
  • Immunology and Microbiology3.3%
  • Other6.2%

Topics

  • Peroxisome Proliferator-Activated Receptors8.3%
  • Drug Transport and Resistance Mechanisms5.6%
  • Cholesterol and Lipid Metabolism3.5%
  • Estrogen and related hormone effects3.5%
  • Adipose Tissue and Metabolism3.4%
  • Liver Disease Diagnosis and Treatment2.6%
  • Other73.1%

Coauthors

All papers

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  1. A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis

    Authors: Bryan Goodwin, Stacey A. Jones, Roger R. Price, Michael A. Watson, David D. McKee, Linda B. Moore, Cristin M. Galardi, Joan G. Wilson, Michael C. Lewis, Matthew E. Roth, Patrick Maloney, Timothy M. Willson, Steven A. Kliewer - Molecular Cell 2000 cited by 1,905

  2. Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

    Authors: Derek J. Parks, Steven G. Blanchard, Randy K. Bledsoe, Gyan Chandra, Thomas G. Consler, Steven A. Kliewer, Julie B. Stimmel, Timothy M. Willson, Ann Marie Zavacki, David D. Moore, Jürgen M. Lehmann - Science 1999 cited by 2,262

  3. Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans

    Authors: Susan Smith, Channa Jayawickreme, David J. Rickard, Edwige Nicodème, Thi Tho Bui, Cathy Simmons, Christine M. Coquery, Jessica Neil, William M. Pryor, David Mayhew, Deepak K. Rajpal, Katrina L. Creech, Sylvia M. Furst, James Lee, Dalei Wu, Fraydoon Rastinejad, Timothy M. Willson, Fabrice Viviani, David C. Morris, John T. Moore, Javier Cote-Sierra - Journal of Investigative Dermatology 2017 cited by 370

  4. Generative and reinforcement learning approaches for the automated de novo design of bioactive compounds

    Authors: Maria Korshunova, Niles Huang, Stephen J. Capuzzi, Dmytro S. Radchenko, Olena Savych, Yuriy S. Moroz, Carrow I. Wells, Timothy M. Willson, Alexander Tropsha, Olexandr Isayev - Communications Chemistry 2022 cited by 104

  5. The promise and peril of chemical probes

    Authors: C.H. Arrowsmith, James E. Audia, Christopher P. Austin, Jonathan B. Baell, Jonathan P. Bennett, Julian Blagg, C. Bountra, Paul E. Brennan, Peter J. Brown, Mark E. Bunnage, Carolyn Buser‐Doepner, Robert M Campbell, Adrian J. Carter, Philip Cohen, Robert A. Copeland, Ben Cravatt, Jayme L. Dahlin, Dashyant Dhanak, A.M. Edwards, Mathias Frederiksen, Stephen V. Frye, Nathanael S. Gray, Charles E. Grimshaw, David Hepworth, Trevor Howe, K. Huber, Jian Jin, Stefan Knapp, Joanne Kotz, Ryan G. Kruger, Derek Lowe, Mary M. Mader, Brian D. Marsden, Anke Mueller‐Fahrnow, Susanne Müller, Rónán C. O’Hagan, John P. Overington, Dafydd R. Owen, Saul H. Rosenberg, Ruth A. Ross, Bryan L. Roth, Matthieu Schapira, Stuart L. Schreiber, Brian K. Shoichet, M. Sundström, Giulio Superti-Furga, Jack Taunton, Leticia Toledo‐Sherman, Chris Walpole, Michael A. Walters, Timothy M. Willson, Paul Workman, Robert N. Young, William J. Zuercher - Nature Chemical Biology 2015 cited by 850

  6. CACHE (Critical Assessment of Computational Hit-finding Experiments): A public–private partnership benchmarking initiative to enable the development of computational methods for hit-finding

    Authors: Suzanne Ackloo, Rima Al‐awar, Rommie E. Amaro, C.H. Arrowsmith, Hatylas Azevedo, Robert A. Batey, Yoshua Bengio, Ulrich A. K. Betz, Cristian Bologa, John D. Chodera, Wendy D. Cornell, Ian Dunham, Gerhard F. Ecker, Kristina Edfeldt, A.M. Edwards, Michael K. Gilson, Cláudia R. Gordijo, Gerhard Heßler, Alexander Hillisch, Anders Hogner, John J. Irwin, Johanna M. Jansen, Daniel Kühn, Andrew R. Leach, Alpha A. Lee, Uta Lessel, Maxwell R. Morgan, John Moult, Ingo Muegge, Tudor I. Oprea, Benjamin Perry, Patrick Riley, Sophie A. L. Rousseaux, Kumar Singh Saikatendu, Vijayaratnam Santhakumar, Matthieu Schapira, Cora Scholten, Matthew H. Todd, Masoud Vedadi, Andrea Volkamer, Timothy M. Willson - Nature Reviews Chemistry 2022 cited by 102

  7. ApoE Promotes the Proteolytic Degradation of Aβ

    Authors: Qingguang Jiang, C.Y. Daniel Lee, Shweta Mandrekar, Brandy Wilkinson, Paige E. Cramer, Noam Zelcer, Karen M. Mann, Bruce T. Lamb, Timothy M. Willson, Jon L. Collins, Jill Richardson, Jonathan D. Smith, Thomas A. Comery, David Riddell, David M. Holtzman, Peter Tontonoz, Gary E. Landreth - Neuron 2008 cited by 867

  8. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

    Authors: Yanqiao Zhang, Florence Ying Lee, Gabriel Barrera, Hans C. Lee, Charisse Vales, Frank J. Gonzalez, Timothy M. Willson, Peter A. Edwards - National Academy of Sciences, Proceedings of the National Academy of Sciences 2006 cited by 937

  9. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

    Authors: Steven A. Kliewer, Scott S. Sundseth, Stacey A. Jones, Peter J. Brown, G. Bruce Wisely, Cecilia S. Koble, Pallavi R. Devchand, Walter Wahli, Timothy M. Willson, James M. Lenhard, Jürgen M. Lehmann - National Academy of Sciences, Proceedings of the National Academy of Sciences 1997 cited by 2,153

  10. 6α-Ethyl-Chenodeoxycholic Acid (6-ECDCA), a Potent and Selective FXR Agonist Endowed with Anticholestatic Activity

    Authors: Roberto Pellicciari, Stefano Fiorucci, Emidio Camaioni, Carlo Clerici, Gabriele Costantino, Patrick Maloney, Antonio Morelli, Derek J. Parks, Timothy M. Willson - Journal of Medicinal Chemistry 2002 cited by 731

  11. An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

    Authors: Jürgen M. Lehmann, Linda B. Moore, Tracey Smith-Oliver, William O. Wilkison, Timothy M. Willson, Steven A. Kliewer - Journal of Biological Chemistry 1995 cited by 3,629

  12. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

    Authors: Mercedes Ricote, Andrew C. Li, Timothy M. Willson, Carolyn Kelly, Christopher K. Glass - Nature 1998 cited by 3,527

  13. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ

    Authors: Robert T. Nolte, G. Bruce Wisely, Stefan Westin, Jeffery E. Cobb, Millard H. Lambert, Riki Kurokawa, Michael G. Rosenfeld, Timothy M. Willson, Christopher K. Glass, Michael V. Milburn - Nature 1998 cited by 1,956

  14. An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

    Authors: Steven A. Kliewer, John T. Moore, Laura Wade, Jeff L. Staudinger, Michael A Watson, Stacey A. Jones, David D. McKee, Beverly B. Oliver, Timothy M. Willson, Rolf Zetterström, Thomas Perlmann, Jürgen M. Lehmann - Cell 1998 cited by 1,549

  15. Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement

    Authors: James D. Vasta, Cesear Corona, Jennifer Wilkinson, Chad Zimprich, James R. Hartnett, Morgan R. Ingold, Kristopher Zimmerman, Thomas Machleidt, Thomas A. Kirkland, Kristin G. Huwiler, Rachel Friedman Ohana, Michael R. Slater, Paul Otto, Mei Cong, Carrow I. Wells, Benedict‐Tilman Berger, Thomas Hanke, Carina Glas, Ke Ding, David H. Drewry, K. Huber, Timothy M. Willson, Stefan Knapp, Susanne Müller, Poncho Meisenheimer, Frank Fan, Keith V. Wood, Matthew B. Robers - Cell chemical biology 2017 cited by 293

  16. The PPARs: From Orphan Receptors to Drug Discovery

    Authors: Timothy M. Willson, Peter J. Brown, Daniel D. Sternbach, Brad R. Henke - Journal of Medicinal Chemistry 2000 cited by 1,804

  17. A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ

    Authors: Gabriel Pascual, Amy L. Fong, Sumito Ogawa, Amir Gamliel, Andrew C. Li, Valentina Perissi, David W. Rose, Timothy M. Willson, Michael G. Rosenfeld, Christopher K. Glass - Nature 2005 cited by 1,234

  18. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

    Authors: J�rgen Lehmann, David D. McKee, M. A. Watson, Timothy M. Willson, John T. Moore, Steven A. Kliewer - Journal of Clinical Investigation 1998 cited by 1,571

  19. The Nuclear Pregnane X Receptor: A Key Regulator of Xenobiotic Metabolism

    Authors: Steven A. Kliewer, Bryan Goodwin, Timothy M. Willson - Endocrine Reviews 2002 cited by 919

  20. Pxr, car and drug metabolism

    Authors: Timothy M. Willson, Steven A. Kliewer - Nature Reviews Drug Discovery 2002 cited by 497

  21. Synthetic LXR ligand inhibits the development of atherosclerosis in mice

    Authors: Sean B. Joseph, Elaine McKilligin, Liming Pei, Michael A. Watson, Alan R. Collins, Bryan Laffitte, Mingyi Chen, Grace Noh, Joanne Goodman, Graham N. Hagger, Jonathan Tran, Tim K. Tippin, Xuping Wang, Aldons J. Lusis, Willa A. Hsueh, Ronald E. Law, Jon L. Collins, Timothy M. Willson, Peter Tontonoz - National Academy of Sciences, Proceedings of the National Academy of Sciences 2002 cited by 939

  22. Crowdsourced mapping of unexplored target space of kinase inhibitors

    Authors: Anna Cichońska, Balaguru Ravikumar, Robert J. Allaway, Fang Wan, Sung‐Joon Park, Olexandr Isayev, Shuya Li, Mike J. Mason, Andrew Lamb, Ziaurrehman Tanoli, Minji Jeon, Sunkyu Kim, Mariya Popova, Stephen J. Capuzzi, Jianyang Zeng, Kristen K. Dang, Gregory Koytiger, Jaewoo Kang, Carrow I. Wells, Timothy M. Willson, User oselot, Mehmet Tan, Team N121, Chih-Han Huang, Edward S.C. Shih, Tsai‐Min Chen, Chih‐Hsun Wu, Wei-Quan Fang, Jhih-Yu Chen, Ming‐Jing Hwang, Team Let_Data_Talk, Xiaokang Wang, Marouen Ben Guebila, Behrouz Shamsaei, Sourav Singh, User thinng, Thin Nguyen, Team KKT, Mostafa Karimi, Di Wu, Zhangyang Wang, Yang Shen, Team Boun, Hakime Öztürk, Elif Özkırımlı, Arzucan Özgür, Team KinaseHunter, Hansaim Lim, Lei Xie, Team AmsterdamUMC-KU-team, Georgi K. Kanev, Albert J. Kooistra, Bart A. Westerman, Team DruginaseLearning, P.J. Terzopoulos, Konstantinos Ntagiantas, Christos Fotis, Leonidas G. Alexopoulos, Dimitri Boeckaerts, Michiel Stock, Bernard De Baets, Yves Briers, Team QED, Yunan Luo, Hailin Hu, Jian Peng, Team METU_EMBLEBI_CROssBAR, Tunca Doğan, Ahmet Süreyya Rifaioğlu, Heval Ataş, Rengül Çetin-Atalay, Volkan Atalay, María Martin, Team DMIS_DK, Minji Jeon, Junhyun Lee, Seongjun Yun, Bumsoo Kim, Buru Chang, Team AI Winter is Coming, Team hulab, Gábor Turu, Ádám Misák, Bence Szalai, László Hunyady, Team ML-Med, Matthias Lienhard, Paul Prasse, Ivo Bachmann, Julia Ganzlin, Gal Barel, Ralf Herwig, Team Prospectors, Davor Oršolić, Bono Lučić, Višnja Stepanić, Tomislav Šmuc, Challenge organizers, Tudor I. Oprea, Avner Schlessinger and 5 more - Nature Communications 2021 cited by 88

  23. Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway

    Authors: Jürgen M. Lehmann, Steven A. Kliewer, Linda B. Moore, Tracey Smith-Oliver, Beverly B. Oliver, Jui Lan Su, Scott S. Sundseth, Deborah A. Winegar, Daniel E. Blanchard, Thomas A. Spencer, Timothy M. Willson - Journal of Biological Chemistry 1997 cited by 1,232

  24. Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation

    Authors: Marie Pariollaud, Julie Gibbs, Thomas Hopwood, Sheila Brown, Nicola Begley, Ryan Vonslow, Toryn Poolman, Baoqiang Guo, Ben Saer, D. Heulyn Jones, James P. Tellam, Stefano Bresciani, Nicholas C. O. Tomkinson, Justyna Wojno-Picon, Anthony W.J. Cooper, Dion A. Daniels, Ryan P. Trump, Daniel Grant, William J. Zuercher, Timothy M. Willson, Andrew S. MacDonald, Brian Bolognese, Patricia L. Podolin, Yolanda Sánchez, Andrew Loudon, David Ray - Journal of Clinical Investigation 2018 cited by 205