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William G. Kaelin

Active 1990–2025

185
Papers
65,039
Citations
135
h-index
183
i10-index

Citations

Citations per year for William G. Kaelin1956: 1 citations1989: 1 citations1990: 1 citations1991: 28 citations1992: 93 citations1993: 184 citations1994: 207 citations1995: 221 citations1996: 270 citations1997: 283 citations1998: 317 citations1999: 501 citations2000: 546 citations2001: 698 citations2002: 901 citations2003: 881 citations2004: 894 citations2005: 807 citations2006: 780 citations2007: 679 citations2008: 654 citations2009: 709 citations2010: 717 citations2011: 676 citations2012: 664 citations2013: 688 citations2014: 723 citations2015: 579 citations2016: 611 citations2017: 650 citations2018: 531 citations2019: 1,623 citations2020: 1,992 citations2021: 1,857 citations2022: 1,411 citations2023: 1,043 citations2024: 1,637 citations2025: 738 citations2026: 13 citations1957–1988: no citations, so these years are not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 8,653 citing papers, 35.8% of this breakdownChina: 2,716 citing papers, 11.2% of this breakdownUnited Kingdom: 1,811 citing papers, 7.5% of this breakdownGermany: 1,324 citing papers, 5.5% of this breakdownJapan: 910 citing papers, 3.8% of this breakdownFrance: 858 citing papers, 3.5% of this breakdownCanada: 824 citing papers, 3.4% of this breakdownItaly: 771 citing papers, 3.2% of this breakdownSpain: 498 citing papers, 2.1% of this breakdownAustralia: 457 citing papers, 1.9% of this breakdownSwitzerland: 436 citing papers, 1.8% of this breakdownNetherlands: 434 citing papers, 1.8% of this breakdown
0%35.8%Other 18.5%

Institutions

Fields

  • Biochemistry, Genetics and Molecular Biology57.3%
  • Medicine35.3%
  • Immunology and Microbiology2.7%
  • Neuroscience1.2%
  • Agricultural and Biological Sciences0.9%
  • Chemistry0.5%
  • Other2.1%

Topics

  • Cancer, Hypoxia, and Metabolism9.4%
  • Cancer-related Molecular Pathways5.1%
  • Epigenetics and DNA Methylation4.2%
  • Ubiquitin and proteasome pathways4.2%
  • RNA modifications and cancer2.7%
  • Protein Degradation and Inhibitors2.2%
  • Other72.2%

Coauthors

All papers

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  1. Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

    Authors: William G. Kaelin, Peter J. Ratcliffe - Molecular Cell 2008 cited by 3,236

  2. The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

    Authors: Gang Lu, Richard E. Middleton, Huahang Sun, MarkVic Naniong, Christopher J. Ott, Constantine S. Mitsiades, Kwok‐Kin Wong, James E. Bradner, William G. Kaelin - Science 2013 cited by 1,582

  3. HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing

    Authors: Mircea Ivan, Keiichi Kondo, Haifeng Yang, William Kim, Jennifer Valiando, Michael Ohh, Adrian Salic, John M. Asara, William S. Lane, William G. Kaelin - Science 2001 cited by 4,724

  4. Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma

    Authors: Diana Miao, Claire A. Margolis, Wenhua Gao, Martin H. Voss, Wei Li, Dylan J. Martini, Craig Norton, Dominick Bossé, Stephanie A. Wankowicz, Dana Cullen, Christine E. Horak, Megan Wind‐Rotolo, Adam Tracy, Marios Giannakis, F. Stephen Hodi, Charles G. Drake, Mark W. Ball, Mohamad E. Allaf, Alexandra Snyder, Matthew D. Hellmann, Thai H. Ho, Robert J. Motzer, Sabina Signoretti, William G. Kaelin, Toni K. Choueiri, Eliezer M. Van Allen - Science 2018 cited by 1,313

  5. Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions

    Authors: Julie J. Miller, L. Nicolas Gonzalez Castro, Samuel K. McBrayer, Michael Weller, Timothy F. Cloughesy, Jana Portnow, Ovidiu C. Andronesi, Jill S. Barnholtz‐Sloan, Brigitta G. Baumert, Mitchel S. Berger, Wenya Linda Bi, Ranjit S. Bindra, Daniel P. Cahill, Susan M. Chang, J Costello, Craig Horbinski, Raymond Y. Huang, Robert B. Jenkins, Keith L. Ligon, Ingo K. Mellinghoff, Burt Nabors, Michael Platten, David A. Reardon, Diana D. Shi, David Schiff, Wolfgang Wick, Hai Yan, Andreas von Deimling, Martin J. van den Bent, William G. Kaelin, Patrick Y. Wen - Neuro-Oncology 2022 cited by 237

  6. Targeting the HIF2–VEGF axis in renal cell carcinoma

    Authors: Toni K. Choueiri, William G. Kaelin - Nature Medicine 2020 cited by 476

  7. Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

    Authors: Samuel K. McBrayer, Jared R. Mayers, Gabriel J. DiNatale, Diana D. Shi, Januka Khanal, Abhishek A. Chakraborty, Kristopher A. Sarosiek, Kimberly J. Briggs, Alissa K. Robbins, Tomasz Sewastianik, Sarah J. Shareef, Benjamin A. Olenchock, Seth J. Parker, Kensuke Tateishi, Jessica B. Spinelli, Mirazul Islam, Marcia C. Haigis, Ryan Looper, Keith L. Ligon, B Bernstein, Ruben D. Carrasco, Daniel P. Cahill, John M. Asara, Christian M. Metallo, Neela H. Yennawar, Matthew G. Vander Heiden, William G. Kaelin - Cell 2018 cited by 374

  8. Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

    Authors: Abhishek A. Chakraborty, Tuomas Laukka, Matti Myllykoski, Alison E. Ringel, Matthew A. Booker, Michael Tolstorukov, Yuzhong Jeff Meng, Samuel R. Meier, Rebecca B. Jennings, Amanda L. Creech, Zachary T. Herbert, Samuel K. McBrayer, Benjamin A. Olenchock, Jacob D. Jaffe, Marcia C. Haigis, Rameen Beroukhim, Sabina Signoretti, Peppi Koivunen, William G. Kaelin - Science 2019 cited by 435

  9. On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models

    Authors: Hyejin Cho, Xinlin Du, James P. Rizzi, Ella Liberzon, Abhishek A. Chakraborty, Wenhua Gao, Ingrid Carvo, Sabina Signoretti, Richard K. Bruick, John A. Josey, Eli M. Wallace, William G. Kaelin - Nature 2016 cited by 461

  10. Influence of Metabolism on Epigenetics and Disease

    Authors: William G. Kaelin, Steven L. McKnight - Cell 2013 cited by 903

  11. 2-Oxoglutarate-dependent dioxygenases in cancer

    Authors: Julie-Aurore Losman, Peppi Koivunen, William G. Kaelin - Nature reviews. Cancer 2020 cited by 213

  12. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

    Authors: James Brugarolas, Kui Lei, Rebecca L. Hurley, Brendan D. Manning, Jan H. Reiling, Ernst Hafen, Lee A. Witters, Leif W. Ellisen, William G. Kaelin - Genes & Development 2004 cited by 1,376

  13. Von Hippel–Lindau disease: insights into oxygen sensing, protein degradation, and cancer

    Authors: William G. Kaelin - Journal of Clinical Investigation 2022 cited by 151

  14. The EGLN-HIF O 2 -Sensing System: Multiple Inputs and Feedbacks

    Authors: Mircea Ivan, William G. Kaelin - Molecular Cell 2017 cited by 275

  15. Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

    Authors: Michael Ohh, Cheol Won Park, Mircea Ivan, Michael A. Hoffman, Tae‐You Kim, Eric Huang, Nikola P. Pavletich, Vincent Chau, William G. Kaelin - Nature Cell Biology 2000 cited by 1,589

  16. Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

    Authors: Peppi Koivunen, Sung-Woo Lee, Christopher G. Duncan, Giselle Y. López, Gang Lü, Shakti Ramkissoon, Julie A. Losman, Päivi Joensuu, Ulrich Bergmann, Stefan Größ, Jeremy Travins, Samuel Weiss, Ryan Looper, Keith L. Ligon, Roel G.W. Verhaak, Hai Yan, William G. Kaelin - Nature 2012 cited by 729

  17. Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling

    Authors: Jung-Hyun Min, Haifeng Yang, Mircea Ivan, Frank B. Gertler, William G. Kaelin, Nikola P. Pavletich - Science 2002 cited by 773

  18. ( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

    Authors: Julie-Aurore Losman, Ryan Looper, Peppi Koivunen, Sung-Woo Lee, Rebekka K. Schneider, Christine M. McMahon, Glenn S. Cowley, David E. Root, Benjamin L. Ebert, William G. Kaelin - Science 2013 cited by 711

  19. De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

    Authors: Diana D. Shi, Milan R. Savani, Michael M. Levitt, Adam C. Wang, Jennifer E. Endress, Cylaina Bird, Joseph Buehler, Sylwia A. Stopka, Michael S. Regan, Yu‐Fen Lin, Vinesh T. Puliyappadamba, Wenhua Gao, Januka Khanal, Laura Evans, J Lee, Lei Guo, Yi Xiao, Min Xu, Bofu Huang, Rebecca B. Jennings, Dennis M. Bonal, Misty S. Martin-Sandoval, Tammie Dang, Lauren C. Gattie, Amy Cameron, Sung-Woo Lee, John M. Asara, Harley I. Kornblum, Tak W. Mak, Ryan Looper, Quang‐Dé Nguyen, Sabina Signoretti, Stefan Gradl, Andreas Sutter, Michael Jeffers, Andreas Janzer, Mark A. Lehrman, Lauren G. Zacharias, Thomas P. Mathews, Julie-Aurore Losman, Timothy E. Richardson, Daniel P. Cahill, Ralph J. DeBerardinis, Keith L. Ligon, Lin Xu, Peter Ly, Nathalie Y.R. Agar, Kalil G. Abdullah, Isaac S. Harris, William G. Kaelin, Samuel K. McBrayer - Cancer Cell 2022 cited by 129

  20. The VHL/HIF axis in clear cell renal carcinoma

    Authors: Chuan Shen, William G. Kaelin - Seminars in Cancer Biology 2012 cited by 385

  21. Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival

    Authors: Matthew G. Oser, Raquel Fonseca, Abhishek A. Chakraborty, Rachel Brough, Alexander Spektor, Rebecca B. Jennings, Abdallah Flaifel, Jesse Novak, Aditi Gulati, Elizabeth Buss, Scott T. Younger, Samuel K. McBrayer, Glenn S. Cowley, Dennis M. Bonal, Quang-Dé Nguyen, Laura Brullé-Soumaré, Paula Taylor, Stefano Cairo, Colm J. Ryan, Elizabeth J. Pease, Kim Maratea, Jon Travers, David E. Root, Sabina Signoretti, David Pellman, Susan Ashton, Christopher J. Lord, Simon T. Barry, William G. Kaelin - Cancer Discovery 2018 cited by 176

  22. The Concept of Synthetic Lethality in the Context of Anticancer Therapy

    Authors: William G. Kaelin - Nature reviews. Cancer 2005 cited by 1,394

  23. Mitochondrial remodeling and ischemic protection by G protein–coupled receptor 35 agonists

    Authors: Gregory A. Wyant, Wenyu Yu, IIias P. Doulamis, Rio S. Nomoto, Mossab Y. Saeed, Thomas Duignan, James D. McCully, William G. Kaelin - Science 2022 cited by 107

  24. Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes

    Authors: Tuomas Laukka, Christopher J. Mariani, Tuukka Ihantola, John Z. Cao, Juho Hokkanen, William G. Kaelin, Lucy A. Godley, Peppi Koivunen - Journal of Biological Chemistry 2015 cited by 302