David Westaway
1981–2025 年に発表
- 90
- 論文数
- 23,268
- 被引用数
- 74
- h 指数
- 89
- i10 指数
被引用数
引用元
国・地域
機関
分野
- Medicine55.1%
- Biochemistry, Genetics and Molecular Biology32.3%
- Neuroscience7.1%
- Nursing2.1%
- Immunology and Microbiology0.6%
- Agricultural and Biological Sciences0.5%
- その他2.3%
トピック
- Alzheimer's disease research and treatments17.6%
- Prion Diseases and Protein Misfolding8.5%
- Neurological diseases and metabolism4.6%
- Trace Elements in Health4.5%
- Cholinesterase and Neurodegenerative Diseases4.5%
- Computational Drug Discovery Methods3.8%
- その他56.5%
共著者
- Peter St George‐Hyslop23
- Stanley B. Prusiner22
- George A. Carlson18
- Paul E. Fraser15
- M. Azhar Chishti11
- Patrick Horne9
- Howard T.J. Mount8
- Jing Yang8
- Christopher Janus7
- Stephen J. DeArmond7
- Fusheng Chen6
- Gerold Schmitt‐Ulms6
- JoAnne McLaurin6
- Joel C. Watts6
- Paul Fraser6
- Paul M. Mathews6
- Peter Mastrangelo6
- Ralph A. Nixon6
- Sang‐Gyun Kang6
- Amie L. Phinney5
- Darlene Groth5
- Kefeng Qin5
- Marilyn Torchia5
- Robert Strome5
全論文
- Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
著者: Ju‐Hyun Lee, Wai Haung Yu, Asok Kumar, Sooyeon Lee, Panaiyur S. Mohan, Corrinne M. Peterhoff, Devin M. Wolfe, Marta Martínez‐Vicente, Ashish C. Massey, Guy Sovak, Yasuo Uchiyama, David Westaway, Ana María Cuervo, Ralph A. Nixon - Cell 2010 被引用: 1,216
- Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695
著者: M. Azhar Chishti, Dun-Shen Yang, Christopher Janus, Amie L. Phinney, Patrick Horne, Jacqueline Pearson, Robert Strome, Noah B. Zuker, James Loukides, Janet French, Sherry Turner, Gianluca Lozza, Mariagrazia Grilli, Suzanne Kunicki, Céline Morissette, Julie Paquette, Francine Gervais, Catherine Bergeron, Paul E. Fraser, George A. Carlson, Peter St George‐Hyslop, David Westaway - Journal of Biological Chemistry 2001 被引用: 954
- Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress
著者: Raymond H. Kim, Patrice D. Smith, Hossein Aleyasin, Shawn Hayley, Matthew Mount, Scott Pownall, Andrew Wakeham, Annick You-Ten, Suneil K. Kalia, Patrick Horne, David Westaway, Andrés M. Lozano, Hymie Anisman, David S. Park, Tak W. Mak - National Academy of Sciences, Proceedings of the National Academy of Sciences 2005 被引用: 707
- Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice
著者: Martin Citron, David Westaway, Weiming Xia, George A. Carlson, Thekla S. Diehl, Georges Lévesque, Kelly Johnson‐Wood, Michael Lee, Peter Seubert, Angela Davis, Dora Kholodenko, Ruth Motter, Robin Sherrington, Billie J. Perry, Hong Yao, Robert Strome, Ivan Lieberburg, Johanna M. Rommens, Soyeon Kim, Dale Schenk, Paul Fraser, Peter St George‐Hyslop, Dennis J. Selkoe - Nature Medicine 1997 被引用: 1,267
- Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
著者: Christopher Janus, Jacqueline Pearson, JoAnne McLaurin, Paul M. Mathews, Ying Jiang, Stephen D. Schmidt, M. Azhar Chishti, Patrick Horne, Donna Heslin, Janet French, Howard T.J. Mount, Ralph A. Nixon, Marc Mercken, Catherine Bergeron, Paul E. Fraser, Peter St George‐Hyslop, David Westaway - Nature 2000 被引用: 1,434
- Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
著者: Dun-Sheng Yang, Philip Stavrides, Panaiyur S. Mohan, Susmita Kaushik, Asok Kumar, Masuo Ohno, Stephen D. Schmidt, Daniel W. Wesson, Urmi Bandyopadhyay, Ying Jiang, Monika Pawlik, Corrinne M. Peterhoff, Austin J. Yang, Donald A. Wilson, Peter St George‐Hyslop, David Westaway, Paul M. Mathews, Efrat Levy, Ana María Cuervo, Ralph A. Nixon - Brain 2010 被引用: 429
- Oleic Acid Ameliorates Amyloidosis in Cellular and Mouse Models of Alzheimer's Disease
著者: Zareen Amtul, David Westaway, David F. Cechetto, Richard Rozmahel - Brain Pathology 2010 被引用: 138
- The cellular prion protein binds copper in vivo
著者: David R. Brown, Kefeng Qin, Jochen Herms, Axel Madlung, Jean Manson, Robert Strome, Paul E. Fraser, Theo P.A. Kruck, Alex von Bohlen, Walter Schulz‐Schaeffer, Armin Giese, David Westaway, Hans A. Kretzschmar - Nature 1997 被引用: 1,270
- Aβ-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Aβ pathology
著者: Shinjiro Fukami, Kaori Watanabe, Nobuhisa Iwata, Jo Haraoka, Bao Lu, Norma P. Gerard, Craig Gérard, Paul Fraser, David Westaway, Peter St George‐Hyslop, Takaomi C. Saido - Neuroscience Research 2002 被引用: 155
- Bioenergetic Mechanisms in Astrocytes May Contribute to Amyloid Plaque Deposition and Toxicity
著者: Wenbin Fu, Diya Shi, David Westaway, Jack H. Jhamandas - Journal of Biological Chemistry 2015 被引用: 89
- Distinct populations of highly potent TAU seed conformers in rapidly progressing Alzheimer’s disease
著者: Chae Kim, Tracy Haldiman, Sang‐Gyun Kang, Lenka Hromádková, Zhuang Zhuang Han, Wei Chen, Frances Lissemore, Alan J. Lerner, Rohan de Silva, Mark L. Cohen, David Westaway, Jiri Safar - Science Translational Medicine 2022 被引用: 60
- Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques
著者: Michael Scott, Dallas Foster, C. Mirenda, Dan Serban, Frank Coufal, Monika Wälchli, Marilyn Torchia, Darlene Groth, George A. Carlson, Stephen J. DeArmond, David Westaway, Stanley B. Prusiner - Cell 1989 被引用: 698
- A cellular gene encodes scrapie PrP 27-30 protein
著者: Bruno Oesch, David Westaway, Monika Wälchli, Michael P. McKinley, Stephen B. H. Kent, Ruedi Aebersold, Ronald A. Barry, Paul Tempst, David B. Teplow, Leroy Hood, Stanley B. Prusiner, Charles Weissmann - Cell 1985 被引用: 1,504
- Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication
著者: Stanley B. Prusiner, Michael Scott, Dallas Foster, Keh‐Ming Pan, Darlene Groth, C. Mirenda, Marilyn Torchia, Shu-Lian Yang, Dan Serban, George A. Carlson, Peter C. Hoppe, David Westaway, Stephen J. DeArmond - Cell 1990 被引用: 870
- Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene
著者: Konrad Basler, Bruno Oesch, Michael Scott, David Westaway, Monika Wälchli, Darlene Groth, Michael P. McKinley, Stanley B. Prusiner, Charles Weissmann - Cell 1986 被引用: 832
- Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model
著者: JoAnne McLaurin, Meredith E. Kierstead, Mary E. Brown, Cheryl A. Hawkes, Mark H. L. Lambermon, Amie L. Phinney, Audrey A. Darabie, Julian E. Cousins, J.E. French, Melissa F Lan, Fusheng Chen, Sydney Sek Ning Wong, Howard T.J. Mount, Paul E. Fraser, David Westaway, Peter St George‐Hyslop - Nature Medicine 2006 被引用: 364
- Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease.
著者: Satyabrata Kar, Stephen P.M. Slowikowski, David Westaway, Howard T.J. Mount - 2004 被引用: 349
- TMP21 is a presenilin complex component that modulates γ-secretase but not ɛ-secretase activity
著者: Fusheng Chen, Hiroshi Hasegawa, Gerold Schmitt‐Ulms, Toshitaka Kawarai, Christopher Böhm, Taiichi Katayama, Yongjun Gu, Nobuo Sanjo, Michael J. Glista, Ekaterina Rogaeva, Yosuke Wakutani, Raphaëlle Pardossi‐Piquard, Xueying Ruan, Anurag Tandon, Frédéric Checler, Philippe Marambaud, Kirk C. Hansen, David Westaway, Peter St George‐Hyslop, Paul Fraser - Nature 2006 被引用: 297
- VEGF significantly restores impaired memory behavior in Alzheimer's mice by improvement of vascular survival
著者: Piotr Religa, Renhai Cao, Dorota Religa, Yuan Xue, Nenad Bogdanović, David Westaway, Hugo H. Marti, Bengt Winblad, Yihai Cao - Scientific Reports 2013 被引用: 130
- Role of Cholesterol in APP Metabolism and Its Significance in Alzheimer’s Disease Pathogenesis
著者: Mahua Maulik, David Westaway, Jack H. Jhamandas, Satyabrata Kar - Molecular Neurobiology 2012 被引用: 117
- Neuroprotective mechanism conferred by 17beta-estradiol on the biochemical basis of Alzheimer's disease
著者: Zareen Amtul, L. Wang, David Westaway, Richard Rozmahel - Neuroscience 2010 被引用: 102
- RNA Therapeutics Directed to the Non Coding Regions of APP mRNA, In Vivo Anti-Amyloid Efficacy of Paroxetine, Erythromycin, and N-acetyl cysteine
著者: Stephanie C. Tucker, Michelle Ahl, Hyun-Hee Cho, Sanghamitra Bandyopadhyay, Gregory D. Cuny, Ashley I. Bush, Lee E. Goldstein, David Westaway, Xudong Huang, Jack T. Rogers - Current Alzheimer Research 2006 被引用: 61
- Presenilin 1 Controls γ-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons
著者: Wim Annaert, Lyne Lévesque, Katleen Craessaerts, Inge Dierinck, Greet Snellings, David Westaway, Peter St George‐Hyslop, Barbara Cordell, Paul Fraser, Bart De Strooper - The Journal of Cell Biology 1999 被引用: 312
- Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model
著者: John Steele, M. Lenard Lachenmayer, Shang Ju, Aryeh Stock, J. Liken, S.H. Kim, Luz Delgado, Iván E. Alfaro, Sebastián Bernales, Giuseppe Verdile, Prashant Bharadwaj, Veer Bala Gupta, Renae K. Barr, A. Friss, Georgia Dolios, Ryan Wang, Dagmar Ringe, Paul E. Fraser, David Westaway, Peter St George‐Hyslop, Piroska E. Szabó, Norman Relkin, Joseph D. Buxbaum, Charles Glabe, Andrew A. Protter, Ralph N. Martins, Michelle E. Ehrlich, Gregory A. Petsko, Zhenyu Yue, Sam Gandy - Molecular Psychiatry 2012 被引用: 112
