Katherine A. High
Active 1989–2025
- 111
- Papers
- 35,185
- Citations
- 91
- h-index
- 110
- i10-index
Citations
Citation sources
Countries
Institutions
- University of Pennsylvania1.6%
- Harvard University1.2%
- Inserm1.2%
- University of Florida1.2%
- University College London1.1%
- Children's Hospital of Philadelphia0.9%
- Other92.8%
Fields
- Biochemistry, Genetics and Molecular Biology68.7%
- Medicine22.3%
- Neuroscience3.8%
- Immunology and Microbiology1.6%
- Engineering1.5%
- Materials Science0.8%
- Other1.3%
Topics
- Virus-based gene therapy research14.7%
- CRISPR and Genetic Engineering8.6%
- RNA Interference and Gene Delivery7.6%
- Retinal Development and Disorders5.9%
- CAR-T cell therapy research4%
- Viral Infectious Diseases and Gene Expression in Insects3.3%
- Other55.9%
Coauthors
- Federico Mingozzi40
- Roland W. Herzog23
- Valder R. Arruda23
- J. Fraser Wright18
- Shangzhen Zhou16
- Xavier M. Anguela13
- Daniel J. Hui12
- Hildegund C.J. Ertl12
- Linda B. Couto12
- Jean Bennett11
- Albert M. Maguire10
- Daniel C. Chung10
- Etiena Basner‐Tschakarjan9
- Kathleen Marshall9
- Timothy C. Nichols9
- J. Nathan Hagstrom8
- Jennifer Wellman8
- Samuel L. Murphy8
- Denise E. Sabatino7
- Eric A. Pierce7
- Francesca Simonelli7
- Glenn F. Pierce7
- Jeannette Bennicelli7
- John E.J. Rasko7
All papers
- Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65 -mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial
Authors: Stephen R. Russell, Jean Bennett, Jennifer Wellman, Daniel C. Chung, Zi-Fan Yu, Amy Tillman, Janet Wittes, Julie Pappas, Okan U. Elci, Sarah McCague, Dominique Cross, Kathleen Marshall, Jean Walshire, Taylor Kehoe, Hannah Reichert, Maria Davis, Leslie Raffini, Lindsey A. George, Fleur Hudson, Laura Dingfield, Xiaosong Zhu, Julia A. Haller, Elliott H. Sohn, Vinit B. Mahajan, Wanda Pfeifer, Michelle T. Weckmann, Chris A. Johnson, Dina Y. Gewaily, Arlene V. Drack, Edwin M. Stone, Katie Wachtel, Francesca Simonelli, Bart P. Leroy, J. Fraser Wright, Katherine A. High, Albert M. Maguire - The Lancet 2017 cited by 1,889
- Gene therapy comes of age
Authors: Cynthia E. Dunbar, Katherine A. High, J. Keith Joung, Donald B. Kohn, Keiya Ozawa, Michel Sadelain - Science 2018 cited by 1,378
- Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response
Authors: Catherine S. Manno, Glenn F. Pierce, Valder R. Arruda, Bertil Glader, Margaret V. Ragni, John E.J. Rasko, Margareth C. Ozelo, Keith Hoots, Philip M. Blatt, Barbara A. Konkle, Michael D. Dake, Robin Kaye, Mahmood Razavi, Albert Zajko, James L. Zehnder, Pradip K. Rustagi, Hiroyuki Nakai, Amy Chew, Debra G. B. Leonard, J Fraser Wright, Ruth Lessard, Jürg M. Sommer, Michael Tigges, Denise E. Sabatino, Alvin Luk, Haiyan Jiang, Federico Mingozzi, Linda Couto, Hildegund C.J. Ertl, Katherine A. High, Mark A. Kay - Nature Medicine 2006 cited by 2,135
- Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B
Authors: Amit C. Nathwani, Edward G. D. Tuddenham, Savita Rangarajan, Cecilia Rosales, Jenny McIntosh, David C. Linch, Pratima Chowdary, Anne Riddell, Arnulfo Pie, Chris F. Harrington, James O’Beirne, Keith Smith, John Pasi, Bertil Glader, Pradip K. Rustagi, Catherine Y. Ng, Mark A. Kay, Junfang Zhou, Yunyu Spence, Christopher L. Morton, James A. Allay, John B. Coleman, Susan Sleep, John M. Cunningham, Deo Kumar Srivastava, Etiena Basner‐Tschakarjan, Federico Mingozzi, Katherine A. High, John T. Gray, Ulrike M. Reiss, Arthur W. Nienhuis, Andrew M. Davidoff - New England Journal of Medicine 2011 cited by 1,843
- Long-Term Safety and Efficacy of Factor IX Gene Therapy in Hemophilia B
Authors: Amit Nathwani, Ulreke M. Reiss, Edward G. D. Tuddenham, Cecilia Rosales, Pratima Chowdary, Jenny McIntosh, Marco Della Peruta, Elsa Lhériteau, Nishal Patel, Deepak B. Thimiri Govinda Raj, Anne Riddell, Jun Pie, Savita Rangarajan, David Bevan, Michael Recht, Yu‐Min Shen, Kathleen G. Halka, Etiena Basner‐Tschakarjan, Federico Mingozzi, Katherine A. High, James A. Allay, Mark A. Kay, Catherine Y. Ng, Junfang Zhou, Maria Cancio, Christopher L. Morton, John T. Gray, Deo Kumar Srivastava, Arthur W. Nienhuis, Andrew M. Davidoff - New England Journal of Medicine 2014 cited by 1,250
- Immune responses to AAV vectors: overcoming barriers to successful gene therapy
Authors: Federico Mingozzi, Katherine A. High - Blood 2013 cited by 920
- Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant
Authors: Lindsey A. George, Spencer K. Sullivan, Adam Giermasz, John E.J. Rasko, Benjamin J. Samelson‐Jones, Jonathan M. Ducore, Adam Cuker, Lisa Sullivan, Suvankar Majumdar, Jerome Teitel, Catherine McGuinn, Margaret V. Ragni, Alvin Luk, Daniel J. Hui, J. Fraser Wright, Yifeng Chen, Yun Liu, Katie Wachtel, Angela Winters, Stefan Tiefenbacher, Valder R. Arruda, Johannes C.M. van der Loo, Olga Zelenaia, Daniel M. Takefman, Marcus E. Carr, Linda B. Couto, Xavier M. Anguela, Katherine A. High - New England Journal of Medicine 2017 cited by 759
- Gene Therapy
Authors: Katherine A. High, Maria Grazia Roncarolo - New England Journal of Medicine 2019 cited by 525
- Entering the Modern Era of Gene Therapy
Authors: Xavier M. Anguela, Katherine A. High - Annual Review of Medicine 2018 cited by 468
- Efficacy, Safety, and Durability of Voretigene Neparvovec-rzyl in RPE65 Mutation–Associated Inherited Retinal Dystrophy
Authors: Albert M. Maguire, Stephen R. Russell, Jennifer Wellman, Daniel C. Chung, Zi‐Fan Yu, Amy Tillman, Janet Wittes, Julie Pappas, Okan U. Elci, Kathleen Marshall, Sarah McCague, Hannah Reichert, Maria Davis, Francesca Simonelli, Bart P. Leroy, J. Fraser Wright, Katherine A. High, Jean Bennett - Ophthalmology 2019 cited by 391
- Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis
Authors: Albert M. Maguire, Francesca Simonelli, Eric A. Pierce, Edward N. Pugh, Federico Mingozzi, Jeannette Bennicelli, Sandro Banfi, Kathleen Marshall, Francesco Testa, Enrico Maria Surace, Settimio Rossi, Arkady Lyubarsky, Valder R. Arruda, Barbara A. Konkle, Edwin M. Stone, Junwei Sun, Jonathan B. Jacobs, Lou F Dell'Osso, Richard W. Hertle, Jian‐xing Ma, T. Michael Redmond, Xiaosong Zhu, Bernd Hauck, Olga Zelenaia, Kenneth S. Shindler, Maureen G. Maguire, J. Fraser Wright, Nicholas J. Volpe, Jennifer Wellman McDonnell, Alberto Auricchio, Katherine A. High, Jean Bennett - New England Journal of Medicine 2008 cited by 2,137
- CD8+ T-cell responses to adeno-associated virus capsid in humans
Authors: Federico Mingozzi, Marcela V. Maus, Daniel J. Hui, Denise E. Sabatino, Samuel L. Murphy, John E.J. Rasko, Margaret V. Ragni, Catherine S. Manno, Jürg M. Sommer, Haiyan Jiang, Glenn F. Pierce, Hildegund C.J. Ertl, Katherine A. High - Nature Medicine 2007 cited by 726
- Multiyear Factor VIII Expression after AAV Gene Transfer for Hemophilia A
Authors: Lindsey A. George, Paul E. Monahan, M. Elaine Eyster, Spencer K. Sullivan, Margaret V. Ragni, Stacy E. Croteau, John E.J. Rasko, Michael Recht, Benjamin J. Samelson‐Jones, Amy MacDougall, Kristen Jaworski, Robert Noble, Marla Curran, Klaudia Kuranda, Federico Mingozzi, Tiffany Chang, Kathleen Z. Reape, Xavier M. Anguela, Katherine A. High - New England Journal of Medicine 2021 cited by 253
- Long-Term Follow-Up of the First in Human Intravascular Delivery of AAV for Gene Transfer: AAV2-hFIX16 for Severe Hemophilia B
Authors: Lindsey A. George, Margaret V. Ragni, John E.J. Rasko, Leslie Raffini, Benjamin J. Samelson‐Jones, Margareth C. Ozelo, Maria Hazbon, Alexa R. Runowski, Jennifer Wellman, Katie Wachtel, Yifeng Chen, Xavier M. Anguela, Klaudia Kuranda, Federico Mingozzi, Katherine A. High - Molecular Therapy 2020 cited by 209
- Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial
Authors: Albert M. Maguire, Katherine A. High, Alberto Auricchio, J. Fraser Wright, Eric A. Pierce, Francesco Testa, Federico Mingozzi, Jeannette Bennicelli, Gui‐Shuang Ying, Settimio Rossi, Ann Fulton, Kathleen Marshall, Sandro Banfi, Daniel C. Chung, Jessica I. W. Morgan, Bernd Hauck, Olga Zelenaia, Xiaosong Zhu, Leslie Raffini, Frauke Coppieters, Elfride De Baere, Kenneth S. Shindler, Nicholas J. Volpe, Enrico Maria Surace, Carmela Acerra, Arkady Lyubarsky, T. Michael Redmond, Edwin M. Stone, Junwei Sun, Jennifer Wellman McDonnell, Bart P. Leroy, Francesca Simonelli, Jean Bennett - The Lancet 2009 cited by 858
- Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges
Authors: Federico Mingozzi, Katherine A. High - Nature Reviews Genetics 2011 cited by 901
- Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial
Authors: Jean Bennett, Jennifer Wellman, Kathleen Marshall, Sarah McCague, Manzar Ashtari, Julie DiStefano‐Pappas, Okan U. Elci, Daniel C. Chung, Junwei Sun, J. Fraser Wright, Dominique Cross, Puya Aravand, Laura Cyckowski, Jeannette Bennicelli, Federico Mingozzi, Alberto Auricchio, Eric A. Pierce, Jason Ruggiero, Bart P. Leroy, Francesca Simonelli, Katherine A. High, Albert M. Maguire - The Lancet 2016 cited by 456
- Durability of Voretigene Neparvovec for Biallelic RPE65-Mediated Inherited Retinal Disease
Authors: Albert M. Maguire, Stephen R. Russell, Daniel C. Chung, Zi‐Fan Yu, Amy Tillman, Arlene V. Drack, Francesca Simonelli, Bart P. Leroy, Kathleen Z. Reape, Katherine A. High, Jean Bennett - Ophthalmology 2021 cited by 188
- Overcoming Preexisting Humoral Immunity to AAV Using Capsid Decoys
Authors: Federico Mingozzi, Xavier M. Anguela, Giulia Pavani, Yifeng Chen, Robert J. Davidson, Daniel J. Hui, Mustafa N. Yazicioglu, Liron Elkouby, Christian Hinderer, Armida Faella, Carolann Howard, Alex Tai, Gregory M. Podsakoff, Shangzhen Zhou, Etiena Basner‐Tschakarjan, J. Fraser Wright, Katherine A. High - Science Translational Medicine 2013 cited by 344
- Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy
Authors: Haiyan Jiang, Linda B. Couto, Susannah Patarroyo‐White, Tongyao Liu, Dea Nagy, Joseph Vargas, Shangzhen Zhou, Ciaran D. Scallan, Jürg M. Sommer, Sharmila Vijay, Federico Mingozzi, Katherine A. High, Glenn F. Pierce - Blood 2006 cited by 320
- AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B
Authors: Catherine S. Manno, Ah Keng Chew, S Hutchison, Peter J. Larson, Roland W. Herzog, V. R. Arruda, Shing Jen Tai, Margaret V. Ragni, Alexis A. Thompson, Margareth C. Ozelo, Linda B. Couto, Debra G. B. Leonard, Freddie A. Johnson, Alan McClelland, Ciaran D. Scallan, Erik D. Skarsgard, Alan W. Flake, Mark A. Kay, Katherine A. High, Bertil Glader - Blood 2003 cited by 747
- AAV-1–mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells
Authors: Federico Mingozzi, J. J. M. Meulenberg, Daniel J. Hui, Etiena Basner‐Tschakarjan, Nicole C. Hasbrouck, Shyrie Edmonson, Natalie A. Hutnick, Michael R. Betts, John J.P. Kastelein, Erik S.G. Stroes, Katherine A. High - Blood 2009 cited by 284
- Clinical development of gene therapy: results and lessons from recent successes
Authors: Sandeep Kumar, David M. Markusic, Moanaro Biswas, Katherine A. High, Roland W. Herzog - Molecular Therapy — Methods & Clinical Development 2016 cited by 229
- Assessing the potential for AAV vector genotoxicity in a murine model
Authors: Hojun Li, Nirav Malani, Shari R Hamilton, Alexander Schlachterman, Giulio Bussadori, Shyrie E. Edmonson, Rachel Shah, Valder R. Arruda, Federico Mingozzi, J. Fraser Wright, Frederic D. Bushman, Katherine A. High - Blood 2010 cited by 228
