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Luke O'neill

Active 1990–2025

Also published as
Luke O’Neill · Luke O'Neill
269
Papers
93,965
Citations
143
h-index
265
i10-index

Citations

Citations per year for Luke O'neill1962: 1 citations1978: 1 citations1984: 3 citations1988: 1 citations1989: 1 citations1991: 7 citations1992: 8 citations1993: 14 citations1994: 11 citations1995: 22 citations1996: 29 citations1997: 32 citations1998: 64 citations1999: 117 citations2000: 161 citations2001: 194 citations2002: 328 citations2003: 343 citations2004: 413 citations2005: 414 citations2006: 514 citations2007: 618 citations2008: 617 citations2009: 722 citations2010: 691 citations2011: 786 citations2012: 797 citations2013: 878 citations2014: 852 citations2015: 913 citations2016: 1,034 citations2017: 1,304 citations2018: 1,514 citations2019: 3,797 citations2020: 5,118 citations2021: 5,089 citations2022: 4,365 citations2023: 3,419 citations2024: 4,771 citations2025: 2,877 citations2026: 59 citations1963–1977: no citations, so these years are not shown1979–1983: no citations, so these years are not shown1985–1987: no citations, so these years are not shown1990: no citations, so this year is not shown

Citation sources

Countries

World map of the countries and regions citing this authorUnited States: 9,992 citing papers, 23.4% of this breakdownChina: 8,328 citing papers, 19.5% of this breakdownUnited Kingdom: 2,455 citing papers, 5.7% of this breakdownGermany: 2,407 citing papers, 5.6% of this breakdownItaly: 1,432 citing papers, 3.3% of this breakdownCanada: 1,227 citing papers, 2.9% of this breakdownFrance: 1,207 citing papers, 2.8% of this breakdownJapan: 1,195 citing papers, 2.8% of this breakdownNetherlands: 1,156 citing papers, 2.7% of this breakdownAustralia: 1,146 citing papers, 2.7% of this breakdownSpain: 898 citing papers, 2.1% of this breakdownSouth Korea: 839 citing papers, 2% of this breakdown
0%23.4%Other 24.5%

Institutions

Fields

  • Biochemistry, Genetics and Molecular Biology32.2%
  • Medicine27.8%
  • Immunology and Microbiology26.8%
  • Neuroscience6.9%
  • Agricultural and Biological Sciences1.6%
  • Nursing1.4%
  • Other3.3%

Topics

  • Immune Response and Inflammation5.4%
  • Inflammasome and immune disorders4.5%
  • Immune cells in cancer4.3%
  • Immune Cell Function and Interaction2.6%
  • Neuroinflammation and Neurodegeneration Mechanisms2.3%
  • interferon and immune responses2.1%
  • Other78.8%

Coauthors

All papers

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  1. Succinate is an inflammatory signal that induces IL-1β through HIF-1α

    Authors: Gillian M. Tannahill, Annie M. Curtis, Juraj Adamik, Eva M. Pålsson‐McDermott, Anne F. McGettrick, Gautam Goel, Christian Frezza, Nicholas J. Bernard, Beth Kelly, Niamh H. Foley, Liang Zheng, Agnès Gardet, Zhen Tong, S. S. Jany, Sinéad C. Corr, Moritz Haneklaus, Brian E. Caffrey, Kerry A. Pierce, Sarah R. Walmsley, Federico C. Beasley, Eoin P. Cummins, Victor Nizet, Moira K. B. Whyte, Cormac T. Taylor, Hening Lin, Seth L. Masters, Eyal Gottlieb, Vincent P. Kelly, Clary B. Clish, Philip E. Auron, Ramnik J. Xavier, Luke O'neill - Nature 2013 cited by 4,111

  2. Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

    Authors: Evanna L. Mills, Beth Kelly, Angela Logan, Ana S.H. Costa, Mukund Varma, Clare Bryant, Panagiotis Tourlomousis, J. Henry M. Däbritz, Eyal Gottlieb, Isabel Latorre, Sinéad C. Corr, Gavin McManus, Dylan G. Ryan, Howard T. Jacobs, Marten Szibor, Ramnik J. Xavier, Thomas Braun, Christian Frezza, Michael P. Murphy, Luke O'neill - Cell 2016 cited by 2,258

  3. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

    Authors: Rebecca C. Coll, Avril A. B. Robertson, Jae Jin Chae, Sarah Higgins, Raúl Muñoz-Planillo, Marco Inserra, Irina Vetter, Lara S. Dungan, Brian G. Monks, Andrea Stutz, Daniel E. Croker, Mark S. Butler, Moritz Haneklaus, Caroline E. Sutton, Gabriel Núñez, Eicke Latz, Daniel L. Kastner, Kingston H. G. Mills, Seth L. Masters, Kate Schroder, Matthew A. Cooper, Luke O'neill - Nature Medicine 2015 cited by 2,784

  4. A guide to immunometabolism for immunologists

    Authors: Luke O'neill, Rigel J. Kishton, Jeff Rathmell - Nature reviews. Immunology 2016 cited by 3,072

  5. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

    Authors: Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag, Dina Dikovskaya, Deepthi Menon, Zbigniew Zasłona, Mark P. Jedrychowski, Ana S.H. Costa, Maureen Higgins, Emily Hams, John Szpyt, Marah C. Runtsch, Martin King, Joanna F. McGouran, Román Fischer, Benedikt M. Kessler, Anne F. McGettrick, Mark Hughes, Richard G. Carroll, Lee M. Booty, Elena V. Knatko, Paul J. Meakin, Michael L.J. Ashford, Louise K. Modis, Gino Brunori, Daniel C. Sévin, Padraic G. Fallon, Stuart T. Caldwell, Edmund R.S. Kunji, Edward T. Chouchani, Christian Frezza, Albena T. Dinkova‐Kostova, Richard C. Hartley, Michael P. Murphy, Luke O'neill - Nature 2018 cited by 1,905

  6. mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

    Authors: Shih‐Chin Cheng, Jessica Quintin, Robert A. Cramer, Kelly M. Shepardson, Sadia Saeed, Vinod Kumar, Evangelos J. Giamarellos‐Bourboulis, Joost H.A. Martens, Nagesha Rao, Ali Aghajanirefah, Ganesh R. Manjeri, Li Yang, Daniela C. Ifrim, Rob J.W. Arts, Brian M. J. W. van der Veer, Peter M.T. Deen, Colin Logie, Luke O'neill, Peter H.G.M. Willems, Frank L. van de Veerdonk, J.W.M. van der Meer, Aylwin Ng, Leo A. B. Joosten, Cisca Wijmenga, Hendrik G. Stunnenberg, Ramnik J. Xavier, Mihai G. Netea - Science 2014 cited by 2,224

  7. Trained immunity: A program of innate immune memory in health and disease

    Authors: Mihai G. Netea, Leo A. B. Joosten, Eicke Latz, Kingston H. G. Mills, Gioacchino Natoli, Hendrik G. Stunnenberg, Luke O'neill, Ramnik J. Xavier - Science 2016 cited by 2,770

  8. Metabolic reprogramming in macrophages and dendritic cells in innate immunity

    Authors: Beth Kelly, Luke O'neill - Cell Research 2015 cited by 1,811

  9. Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

    Authors: Eva M. Pålsson‐McDermott, Annie M. Curtis, Gautam Goel, Mario Lauterbach, Frederick J. Sheedy, Laura E. Gleeson, Mirjam W.M. van den Bosch, Susan R. Quinn, Raquel Domingo-Fernandéz, Daniel Johnston, Jian‐kang Jiang, William J. Israelsen, Joseph Keane, Craig J. Thomas, Clary B. Clish, Matthew G. Vander Heiden, Ramnik J. Xavier, Luke O'neill - Cell Metabolism 2015 cited by 1,375

  10. Macrophage Immunometabolism: Where Are We (Going)?

    Authors: Jan Van den Bossche, Luke O'neill, Deepthi Menon - Trends in Immunology 2017 cited by 1,137

  11. Immunometabolism governs dendritic cell and macrophage function

    Authors: Luke O'neill, Edward J. Pearce - The Journal of Experimental Medicine 2015 cited by 1,641

  12. The Role of HIF in Immunity and Inflammation

    Authors: Anne F. McGettrick, Luke O'neill - Cell Metabolism 2020 cited by 750

  13. Mitochondria are the powerhouses of immunity

    Authors: Evanna L. Mills, Beth Kelly, Luke O'neill - Nature Immunology 2017 cited by 1,150

  14. The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

    Authors: Alexander Hooftman, Stefano Angiari, Svenja Hester, Sarah E. Corcoran, Marah C. Runtsch, Chris Ling, Melanie C. Ruzek, Peter F. Slivka, Anne F. McGettrick, Kathy Banahan, Mark Hughes, Alan D. Irvine, Román Fischer, Luke O'neill - Cell Metabolism 2020 cited by 588

  15. Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

    Authors: Richard D. Gordon, Eduardo A. Albornoz, Daniel C. Christie, Monica R. Langley, Vinod Kumar, Susanna Mantovani, Avril A. B. Robertson, Mark S. Butler, Dominic B. Rowe, Luke O'neill, Anumantha G. Kanthasamy, Kate Schroder, Matthew A. Cooper, Trent M. Woodruff - Science Translational Medicine 2018 cited by 890

  16. Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

    Authors: Rob J.W. Arts, Boris Novakovic, Rob ter Horst, Agostinho Carvalho, Siroon Bekkering, Ekta Lachmandas, Fernando Rodrigues, Ricardo Silvestre, Shih‐Chin Cheng, Shuang-Yin Wang, Ehsan Habibi, Luís G. Gonçalves, Inês Mesquita, Cristina Cunha, Arjan van Laarhoven, Frank L. van de Veerdonk, David L. Williams, J.W.M. van der Meer, Colin Logie, Luke O'neill, Charles A. Dinarello, Niels P. Riksen, Reinout van Crevel, Clary B. Clish, Richard A. Notebaart, Leo A. B. Joosten, Hendrik G. Stunnenberg, Ramnik J. Xavier, Mihai G. Netea - Cell Metabolism 2016 cited by 858

  17. Itaconate: the poster child of metabolic reprogramming in macrophage function

    Authors: Luke O'neill, Maxim N. Artyomov - Nature reviews. Immunology 2019 cited by 625

  18. HIF1α and metabolic reprogramming in inflammation

    Authors: Sarah E. Corcoran, Luke O'neill - Journal of Clinical Investigation 2016 cited by 738

  19. Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages

    Authors: Marah C. Runtsch, Stefano Angiari, Alexander Hooftman, Ridhima Wadhwa, Yanling Zhang, Yunan Zheng, Joseph S. Spina, Melanie C. Ruzek, M.A. Argiriadi, Anne F. McGettrick, Rui Santalla Méndez, Alessia Zotta, Christian G. Peace, Aoife Walsh, Roberta Chirillo, Emily Hams, Padraic G. Fallon, Ranjith Jayaraman, Kamal Dua, Alexandra C. Brown, Richard Kim, Jay C. Horvat, Philip M. Hansbro, Chu Wang, Luke O'neill - Cell Metabolism 2022 cited by 318

  20. Trained immunity, tolerance, priming and differentiation: distinct immunological processes

    Authors: Maziar Divangahi, Peter Aaby, Shabaana A. Khader, Luis B. Barreiro, Siroon Bekkering, Triantafyllos Chavakis, Reinout van Crevel, Nigel Curtis, Andrew R. DiNardo, Jorge Domínguez‐Andrés, Raphaël Duivenvoorden, Stephanie Fanucchi, Zahi A. Fayad, Elaine Fuchs, Mélanie Hamon, Kate L. Jeffrey, Nargis Khan, Leo A. B. Joosten, Eva Kaufmann, Eicke Latz, Giuseppe Matarese, J.W.M. van der Meer, Musa M. Mhlanga, Simone J.C.F.M. Moorlag, Willem J. M. Mulder, Shruti Naik, Boris Novakovic, Luke O'neill, Jordi Ochando, Keiko Ozato, Niels P. Riksen, Robert W. Sauerwein, Edward R. Sherwood, Andreas Schlitzer, Joachim L. Schultze, Michael H. Sieweke, Christine Stabell Benn, Henk G. Stunnenberg, Joseph C. Sun, Frank L. van de Veerdonk, Sebastian Weis, David L. Williams, Ramnik J. Xavier, Mihai G. Netea - Nature Immunology 2020 cited by 595

  21. A guiding map for inflammation

    Authors: Mihai G. Netea, Frances R. Balkwill, Michel Chonchol, Fabio Cominelli, Marc Y. Donath, Evangelos J. Giamarellos‐Bourboulis, Douglas T. Golenbock, Mark S. Gresnigt, Michael T. Heneka, Hal M. Hoffman, Richard S. Hotchkiss, Leo A. B. Joosten, Daniel L. Kastner, Martin Körte, Eicke Latz, Peter Libby, Thomas Mandrup‐Poulsen, Alberto Mantovani, Kingston H. G. Mills, Kristen L. Nowak, Luke O'neill, Peter Pickkers, Tom van der Poll, Paul M. Ridker, Joost Schalkwijk, David A. Schwartz, Britta Siegmund, Clifford J. Steer, Herbert Tilg, Jos W.M. van der Meer, Frank L. van de Veerdonk, Charles A. Dinarello - Nature Immunology 2017 cited by 823

  22. Krebs Cycle Reborn in Macrophage Immunometabolism

    Authors: Dylan G. Ryan, Luke O'neill - Annual Review of Immunology 2020 cited by 427

  23. Macrophage fumarate hydratase restrains mtRNA-mediated interferon production

    Authors: Alexander Hooftman, Christian G. Peace, Dylan G. Ryan, Emily A. Day, Ming Yang, Anne F. McGettrick, Maureen Yin, Erica N. Montano, Lihong Huo, Juliana E. Toller-Kawahisa, Vincent Zecchini, Tristram A.J. Ryan, Alfonso Bolado‐Carrancio, Alva M. Casey, Hiran A. Prag, Ana S.H. Costa, Gabriela De Los Santos, Mariko Ishimori, Daniel J. Wallace, Swamy Venuturupalli, Efterpi Nikitopoulou, Norma Frizzell, Cecilia Johansson, Alex von Kriegsheim, Michael P. Murphy, Caroline A. Jefferies, Christian Frezza, Luke O'neill - Nature 2023 cited by 224

  24. Targeting immunometabolism as an anti-inflammatory strategy

    Authors: Eva M. Pålsson‐McDermott, Luke O'neill - Cell Research 2020 cited by 564